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The Award database is continually updated throughout the year. As a result, data for FY22 is not expected to be complete until September, 2023.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Energy & Power Dense Supercapacitor: On-Chip Integration in MEMs Fabrication

    SBC: MAINSTREAM ENGINEERING CORPORATION            Topic: DMEA21A001

    Due to recent advances in the field of microelectronics, there is an increasing demand for micro-sized energy storage devices that are capable of being incorporated into and provide energy for MEMS devices. In order to continue to enable this technological growth, and the benefits that stem from it, the storage density of electrical energy must also continually be improved, especially with respect ...

    STTR Phase I 2021 Department of DefenseDefense Microelectronics Activity
  2. Computer-aided design for improved lantibiotics

    SBC: Oragenics, Inc.            Topic: 400

    ABSRACT With the ever-increasing problem of antibiotic resistance and the concurrent use of antibiotics in the food chain and in agriculture, there is an urgent and unmet need for new classes of antibiotics. Lantibiotics represent a large untapped pipeline of attractive scaffolds for the development of novel antibiotics. Previous in vitro and in vivo studies support the concept that lantibiotics a ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  3. A Peptide-Based Polyplex Platform for Nucleotides Delivery to the Sites of Inflammation

    SBC: Trasir Therapeutics, Inc.            Topic: 100

    AbstractRNA interference (RNAi) is an evolutionary conserved mechanism for post transcriptional control of protein expression in which short double-stranded RNA target specific messenger RNA (mRNA) for degradation, thus inhibiting protein translation. siRNA has great potential to revolutionize medicine by enabling highly specific and efficient silencing of proteins involved in disease pathogenesis ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  4. A MEMS-Based High-Throughput Photostimulation Device with Commercial Backplane Integration

    SBC: BOULDER NONLINEAR SYSTEMS, INC.            Topic: NIMH

    Boulder Nonlinear Systems (BNS) and Prof. Rikky Muller at UC-Berkeley propose a two-phase effort to address current speed limitations in holographic photostimulation. Specifically, the proposed innovations aim to achieve streaming of high-resolution holograms at up to 10,000 frames per second (fps) to enable closed-loop optogenetic control.Optical imaging and photostimulation have emerged as compl ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a biomarker panel for screening and early detection of gynecological cancers

    SBC: MDDx, Inc.            Topic: 102

    PROJECT SUMMARY It is estimated that more than 80,000 women will be diagnosed with ovarian (OvCA) and endometrial (EndoCA) cancers this year in the U.S. and this will result in the death of 26,000 women. There are no screening tests for either of these two female-specific cancers which also disproportionally affect ethnically distinct populations. For both cancers, detection of early stage, locali ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  6. Controlled-release Microbeads to Replace Growth Factors in Fetal Bovine Serum

    SBC: StemCultures, LLC            Topic: 400

    Project Summary / Abstract: Fetal bovine serum (FBS) contains a variety growth factors (GFs) and GF-stabilizing agents that have a potent influence on cell behavior. Lot-to-lot variability of FBS, however, results in fluctuation of initial GF levels. These fluctuations are further complicated by time-dependent decay at rates unique to each GF, resulting in changing GF ratios over time. These three ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Risk modeling and shared decision making for postpartum depression

    SBC: Iris OB Health Inc.            Topic: 104

    PROJECT ABSTRACT Postpartum depression (PPD) is a strikingly common and potentially life-threatening mental health condition, affecting 1 in 5 mothers in the US. PPD poses serious health concerns, not only to mothers but also their children and the family. PPD has been associated with increased infant mortality, higher rates of hospitalizations, impaired mother-child attachment, developmental prob ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  8. A multitargeted nanocarrier inhibitor of undruggable transcription factors for treating castration resistant prostate cancer

    SBC: PARABON NANOLABS, INC.            Topic: 102

    Project Summary This project addresses the critical need for treatments of castration resistant prostate cancer (CRPC) by proposing to engineer and develop a novel, nanostructured pharmaceutical (P-TRIS5) which will target tumor cells and deliver two potent, synergistic therapeutics (an siRNA and a small molecule) to inhibit the androgen receptor and RUNX, two commonly implicated transcription fac ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Small molecule inhibitors of influenza virus nucleoprotein

    SBC: ALEXANDER BIODISCOVERIES            Topic: NIAID

    Influenza is a continuing worldwide public health threat, with seasonal activity that is not adequately controlled by the yearly vaccine program. The severity of this problem is likely to increase with emergence of new influenza virus strains in the human population, and this situation is made even more complex by the COVID-19 pandemic. Both COVID-19 and the 2009 H1N1 influenza pandemics are remin ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. Use of polymer-peptide system to deliver cells for intervertebral disc regeneration

    SBC: BioRestorative Therapies, Inc.            Topic: NIAMS

    Abstract Low back pain affects millions of Americans and causes $100 billion socioeconomic loss annually. One of the prominent risk factors is intervertebral disc degeneration. Current treatments are palliative for relieving pain without restoring disc biology or biomechanics. Pain recurrence is common. Spinal fusion is popular, but it is limited by high failure rate (up to 30%) while predisposes ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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