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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Energy & Power Dense Supercapacitor: On-Chip Integration in MEMs Fabrication

    SBC: MAINSTREAM ENGINEERING CORP            Topic: DMEA21A001

    Due to recent advances in the field of microelectronics, there is an increasing demand for micro-sized energy storage devices that are capable of being incorporated into and provide energy for MEMS devices. In order to continue to enable this technological growth, and the benefits that stem from it, the storage density of electrical energy must also continually be improved, especially with respect ...

    STTR Phase I 2021 Department of DefenseDefense Microelectronics Activity
  2. Computer-aided design for improved lantibiotics

    SBC: Oragenics, Inc.            Topic: 400

    ABSRACT With the ever-increasing problem of antibiotic resistance and the concurrent use of antibiotics in the food chain and in agriculture, there is an urgent and unmet need for new classes of antibiotics. Lantibiotics represent a large untapped pipeline of attractive scaffolds for the development of novel antibiotics. Previous in vitro and in vivo studies support the concept that lantibiotics a ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  3. A Peptide-Based Polyplex Platform for Nucleotides Delivery to the Sites of Inflammation

    SBC: Trasir Therapeutics, Inc.            Topic: 100

    AbstractRNA interference (RNAi) is an evolutionary conserved mechanism for post transcriptional control of protein expression in which short double-stranded RNA target specific messenger RNA (mRNA) for degradation, thus inhibiting protein translation. siRNA has great potential to revolutionize medicine by enabling highly specific and efficient silencing of proteins involved in disease pathogenesis ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  4. A MEMS-Based High-Throughput Photostimulation Device with Commercial Backplane Integration

    SBC: BOULDER NONLINEAR SYSTEMS, INC.            Topic: NIMH

    Boulder Nonlinear Systems (BNS) and Prof. Rikky Muller at UC-Berkeley propose a two-phase effort to address current speed limitations in holographic photostimulation. Specifically, the proposed innovations aim to achieve streaming of high-resolution holograms at up to 10,000 frames per second (fps) to enable closed-loop optogenetic control.Optical imaging and photostimulation have emerged as compl ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a biomarker panel for screening and early detection of gynecological cancers

    SBC: MDDx, Inc.            Topic: 102

    PROJECT SUMMARY It is estimated that more than 80,000 women will be diagnosed with ovarian (OvCA) and endometrial (EndoCA) cancers this year in the U.S. and this will result in the death of 26,000 women. There are no screening tests for either of these two female-specific cancers which also disproportionally affect ethnically distinct populations. For both cancers, detection of early stage, locali ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  6. Enabling rapid and effective stroke thrombectomy procedures from a Transradial approach:Combining introducer sheath, guide catheter, and distal access catheter into a single device.

    SBC: CONWAY MEDICAL LLC            Topic: 105

    PROJECT SUMMARY/ABSTRACT This proposal’s long-term goal is to improve the care of patients suffering from Large Vessel Occlusion Acute Ischemic stroke (LVO AIS). Emergent, catheter-based thrombectomy is an established treatment for LVO AIS. Still, substantial limitations remain. Rapid catheterization of distal, intracranial vessels represents an essential feature of successful thrombectomy proce ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Translation of Interferometric-based Free-solution Assay Methodology

    SBC: MERU BIOTECHNOLOGIES            Topic: 300

    Project Summary: Lung cancer is the leading cause of cancer-related deaths in the United States. Low dose chest computed tomography (CT) screening programs that target high-risk individuals can reduce lung cancer-specific mortality by 20% and overall mortality by 6.9%. There is a growing movement to implement this life saving screening into routine practice, with endorsements from the U.S. Prevent ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  8. Controlled-release Microbeads to Replace Growth Factors in Fetal Bovine Serum

    SBC: STEM CULTURES LLC            Topic: 400

    Project Summary / Abstract: Fetal bovine serum (FBS) contains a variety growth factors (GFs) and GF-stabilizing agents that have a potent influence on cell behavior. Lot-to-lot variability of FBS, however, results in fluctuation of initial GF levels. These fluctuations are further complicated by time-dependent decay at rates unique to each GF, resulting in changing GF ratios over time. These three ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Bioethical Considerations for Building, Evaluating, and Implementing Artificial Intelligence in Perinatal Mood and Anxiety Disorders

    SBC: Iris OB Health Inc.            Topic: 104

    PROJECT SUMMARY Postpartum depression (PPD) is a common, yet treatable illness if detected early, but it can also have deleterious effects to the mother and child if left untreated. Routine screening for PPD is considered best practice but does not consistently occur due to time and resource constraints. As a result, therapeutic interventions are initiated late and many PPD cases go undetected alt ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. A multitargeted nanocarrier inhibitor of undruggable transcription factors for treating castration resistant prostate cancer

    SBC: PARABON NANOLABS, INC.            Topic: 102

    Project Summary This project addresses the critical need for treatments of castration resistant prostate cancer (CRPC) by proposing to engineer and develop a novel, nanostructured pharmaceutical (P-TRIS5) which will target tumor cells and deliver two potent, synergistic therapeutics (an siRNA and a small molecule) to inhibit the androgen receptor and RUNX, two commonly implicated transcription fac ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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