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Thegoal is to develop asoftwaretool that implementsa novelapproach applicableto fitgeneral pharmacologic, toxicology, or other biomedical data, that mayexhibita non-monotonic dose-responserelationship for which thecurrent parametricmodels fail. Thesoftwareexplores dose-responserelationships using both monotonicand non-monotonicmodels,and estimates theassociated doseresponsecurves,which can further ...

Glucose abnormalities significantly affect patient morbidity and mortality. Currently, glycemic control is achieved via medications and exogenous insulin regimens that are costly both in terms of qualified personnel and consumables. Furthermore, none of these approaches are curative. Strategies under development such artificial pancreases do not necessarily address these limitations because they w ...

Methods for interconversion between cell types (cellular reprogramming) are currently discovered through resource intensive trial and error. Experiments may test a multitude of transcription factors to identify correct combinations that influence cell fate. In addition, reprogramming approaches commonly use stem cell intermediates such as induced pluripotent stem cells (iPSCs), which are generated ...

Nanoscale, material sensitive, imaging techniques are critical for progress in many disciplines as we learn to master science and technology at the smallest dimensions — on the nanometer to atomic-scale. However, progress in both science and technology is becoming increasingly limited by the constraints of current imaging techniques and metrologies. Fortunately, by combining coherent extreme UV ...

Additive manufacturing (AM) has rapidly evolved into a valuable technique for making parts which, at times, cannot be fabricated through conventional machining methods, or for fabrication of small quantities of complex parts. One challenge in the area of AM is the lack of real-time feedback on the fabrication process and the quality of the part being made. This is especially critical given the rel ...

he Storable Clean Ethane-ethylene Nitrous Engine (SCENE) is a proposed technology designed to provide upper stages and spacecraft with non-toxic, liquid, non-cryogenic, high-performance propulsion with an Isp on the order of 300 seconds. The propellant components are stored as liquids under their saturated vapor pressures. With the SCENE, nitrous oxide is used as an autogenously pressurized oxidiz ...

Uncertainty Reduction in High Speed Flight Vehicle Modeling | Approved for Public Release 18-MDA-9707 (3 Jul 18)

Uncertainty Reduction in High Speed Flight Vehicle Modeling | Approved for Public Release 18-MDA-9707 (3 Jul 18)

Based on the results of our Phase I work, one significant barrier to optimizing battery performance lies in understanding the relationship between bulk solids and particle flow properties and the flow into the die. Our hypothesis: an increase in quality batteries production can be achieved if powder preparation process can be optimized and the die filling process controlled. We feel that control o ...

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