Award Data

Thegoal is to develop asoftwaretool that implementsa novelapproach applicableto fitgeneral pharmacologic, toxicology, or other biomedical data, that mayexhibita non-monotonic dose-responserelationship for which thecurrent parametricmodels fail. Thesoftwareexplores dose-responserelationships using both monotonicand non-monotonicmodels,and estimates theassociated doseresponsecurves,which can further ...

Methods for interconversion between cell types (cellular reprogramming) are currently discovered through resource intensive trial and error. Experiments may test a multitude of transcription factors to identify correct combinations that influence cell fate. In addition, reprogramming approaches commonly use stem cell intermediates such as induced pluripotent stem cells (iPSCs), which are generated ...

Additive manufacturing (AM) has rapidly evolved into a valuable technique for making parts which, at times, cannot be fabricated through conventional machining methods, or for fabrication of small quantities of complex parts. One challenge in the area of AM is the lack of real-time feedback on the fabrication process and the quality of the part being made. This is especially critical given the rel ...

Based on the results of our Phase I work, one significant barrier to optimizing battery performance lies in understanding the relationship between bulk solids and particle flow properties and the flow into the die. Our hypothesis: an increase in quality batteries production can be achieved if powder preparation process can be optimized and the die filling process controlled. We feel that control o ...

Autoclaves are typically used to fabricate high-quality composite components with acceptable thermal properties and low void volume. They provide elevated temperature processing cycles and external pressure required for adequate compaction to achieve these desired properties. However, autoclaves represent large capital and energy investment while limiting the size of fabricated parts and productio ...

For this research program, Mainstream will collaborate with Colorado State University (CSU) to develop a nanostructured heater capable of curing aerospace grade composites out-of-autoclave (OOA). The use of autoclaves is the primary cost driver in composite manufacturing due to size limitations, long processing times, and inefficient energy usage. Therefore, the Navy is looking to develop a nanost ...

Barron Associates has teamed with a prominent researcher in the field of formal verification of cyber physical systems to propose a new paradigm in runtime assurance for complex autonomous systems controlled and operated by artificial machine intelligence. A two-stage approach is considered in which formal verification processes are first performed offline at algorithm design time. Online, during ...

The performance of a composite material is heavily influenced by the strength and toughness of the interlaminar region, which is the resin rich area between the plies of a fiber reinforced composite. The interlaminar region generally provides a direct path for crack propagation since no continuous reinforcement is present and is often the cause of failure in materials subjected to cyclic loading s ...

The development of a catastrophic optical damage model for quantum cascade lasers describing instantaneous laser damage at high optical power levels is proposed. The model will be validated by comparison to experimental data. Based on obtained results, changes to laser design and laser fabrication resulting in an increased damage threshold will be implemented. The work will ultimately result into ...

The primary objective is to develop electric machine/drive topologies and power architectures that achieve the power densities required for 50% more power without the increase in weight or space requirements. In addition to PMSM-based designs, two new machine topologies will be considered. The first is a trapped flux coreless (TFC) machine that utilizes superconducting pucks made of YBCO to produc ...