Award Data

The objective of the proposed study is to develop a subcutaneous implant of risperidone that provides consistent therapeutic blood levels of the drug for 6 months after a single administration. The device is implanted during a simple, 10-minute, in-office procedure with local anesthetic. The benefits of the product include improved medication adherence, fewer relapses, ability to withdraw the medi ...

During altitude-induced hypoxia, operator cognitive and physical capacity degrades, compromising individual and team performance. Cognitive degradation is linked to falling brain energy levels, increased reliance on anaerobic energy production and lactate accumulation. Ketones are the evolutionary alternative substrate to glucose for brain metabolic requirements; previous studies demonstrated that ...

This project will develop a Socially-Assistive Robot (SAR) to provide cognitive training, in the form of learning to play the piano, to improve cognitive functioning and reduce feelings of loneliness in socially-isolated older adults. The SAR will administer cognitive training via guided practice on a set of standard piano lesson tasks designed to reflect particular cognitive functions: memory, at ...

AbstractCaring for a loved one with Alzheimer’s disease, frontotemporal dementia, or another neurodegenerative disease is a highly meaningful part of family life. However, the associated burden and strain can have adverse effects on caregivers including mental and physical health problems, reduced well-being, and increased mortality. These effects, in turn, can compromise care quality and shorte ...

Project Summary/Abstract Advanced Medical Electronics Corporation and our partners propose to develop a Socially-Assistive Robot (SAR) system for persons with dementia (PWD),(mild cognitive impairment, Alzheimerandapos;s disease, or other dementias), who are living in assisted living facilities. The proposed system uses Augmented Intelligence (AI) to communicate with the PWD in natural language. T ...

In Phase I Ceebus demonstrated the feasibility of an underwater, acoustic, direct-sequence spread-spectrum communication architecture, including actual data transfers and decoded message recovery. All of the communication algorithms were post-processed and communication was performed with a single piezo transducer. Prototype development is the next step in delivering a system that offers real-time ...

PROJECT SUMMARY The goal of this project is to complete the preclinical development of Elex Biotechandapos;s novel compounds that target and treat the underlying molecular cause of catecholaminergic polymorphic ventricular tachycardia (CPVT) CPVT. There are no FDA-approved treatments for CPVT, a rare genetic disorder affecting 1/10,000 individuals, with typical onset in children 7-9 years of age a ...

Project Summary This proposed project will develop and field-test a device that accurately monitors and controls the circadian stimulus (CS) for Alzheimer disease (AD) and Alzheimer-disease-related dementia (ADRD) patients in nursing homes. Human biology has evolved to have two distinct optical systems: the visual system, by which we see and process images, and the circadian system, which regulate ...

SOF combat swimmers have a need for the continuous monitoring of each others relative position while diving and for the capability of being able to communicate with each other to help establish a common operational picture (COP).The C3SA system was previously developed under SBIR Topic SOCOM08-001 thru the receipt of both Phase I and Phase II SBIR awards.The C3SA established a stand-alone network ...

ABSTRACT Yellow fever virus (YFV) represents a mosquito-borne emerging/re-emerging human pathogen that causes 20- 50% mortality and is endemic in andgt;40 countries. The current live attenuated YFV vaccine was developed in 1936 and following the establishment of a virus seed lot system, it has not been modified or otherwise improved in over 50 years. According to the CDC, this vaccine causes 47 se ...