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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Hybrid System for Ultrasound Signal, Spectral, and Image Analyses to Enhance Meat Quality Evaluation in Food Animals

    SBC: BIOTRONICS, INC            Topic: 83

    Determining meat quality attributes in food animals is essential for genetic selection, sorting, and marketing. Ultrasound techniques have the potential to benefit the swine industry for improvements in both quality and yield measures by non-destructive and non-invasive means. Biotronics, Inc. has developed and markets products for evaluation of percent intramuscular fat (% IMF) in longissimus dor ...

    SBIR Phase II 2010 Department of Agriculture
  2. Ambient Processing and Nutritional Assessment of Reduced-Trypsin-Inhibitor & Low Oligosaccharide Soybean Products

    SBC: SCHILLINGER SEED INC            Topic: 85

    The current state of the art of soybean processing requires heat processing to eliminate anti-nutrition factors and make the protein available for digestion. The proposed research will investigate the opportunity to process a new soybean variety that has been traditionally bred (not genetically modified) to eliminate and/or significantly reduce these anti-nutrition factors. This research will inve ...

    SBIR Phase II 2010 Department of Agriculture
  3. Replicon Particle Vaccine for White Spot Syndrome Virus in Marine Shrimp

    SBC: HARRISVACCINES, INC.            Topic: 87

    WSSV is the most serious disease in farmed marine shrimp causing considerable financial losses throughout the last decade across the globe. It infects a wide variety of crustacean hosts including numerous species of wild and cultured marine shrimp, crayfish, and prawns. Although a multitude of vaccination strategies have been attempted with mixed results, no viable commercial product exists on the ...

    SBIR Phase I 2010 Department of Agriculture
  4. SapC-DOPS nanovesicles for Treating Glioblastoma Multiforme

    SBC: BEXION PHARMACEUTICALS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Our goal is to develop a new molecular entity with a novel mechanism of action for targeting and eliminating glioblastoma multiforme (GBM, high grade glioma), a deadly and invasive brain tumor with no effective treatment. Of the 12,000 patients expected to be diagnosed with GBM this year, most will succumb within the first year. Clearly, there is an urgent ...

    SBIR Phase II 2010 Department of Health and Human Services
  5. Development of Multivalent Vaccines Against Yellow Fever and Arena Viruses

    SBC: BIOPROTECTION SYSTEMS CORP.            Topic: NIAID

    DESCRIPTION (provided by applicant): Indigenous population, travelers and troops present in Africa and South America are clearly at risk of exposure to several arenaviruses. Several human pathogenic arenaviruses, e.g., Lassa and Junin viruses, are listed on the NIAID's Priority Pathogens and CDC's Bioterrorism Agents Lists and can cause a deadly hemorrhagic fever. No effective and safe vaccine is ...

    SBIR Phase I 2010 Department of Health and Human Services
  6. Concurrent Upper/Lower Extremity SCI Exercise with Stimulation

    SBC: CUSTOMKYNETICS, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): This proposal will develop a FES-augmented recumbent stepper that elicits lower extremity involvement through electrical stimulation while upper extremity involvement is volitionally controlled by the client. Exercise for people with spinal cord injury not only enhances physical fitness but has the potential to slow or reverse many of the secondary complication ...

    SBIR Phase I 2010 Department of Health and Human Services
  7. Development of a Humanized Pig Model of Cystic Fibrosis

    SBC: EXEMPLAR GENETICS, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR gene encodes a chloride channel that regulates ion flow across epithelial cell membranes. Most CF patients have a mutation that deletes phenylalanine 508 (?F508) and prevents CFTR from being properly processed and delivered to cell membra ...

    SBIR Phase II 2010 Department of Health and Human Services
  8. Development of a Porcine Model of Atherosclerosis

    SBC: EXEMPLAR GENETICS, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Atherosclerosis is the primary cause of cardiovascular disease, which is the most common cause of death in the United States. Atherosclerosis is characterized by the accumulation of lipids, cholesterol, calcium deposits, and cellular debris in vessel walls, and results in plaque formation, arterial obstruction, and diminished blood flow to organs. These plaqu ...

    SBIR Phase I 2010 Department of Health and Human Services
  9. Optimization of U1 Adaptor Technology

    SBC: INTEGRATED DNA TECHNOLOGIES, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Our understanding of complex biological phenomena and disease progression has led to the realization that changes in the expression of genes underlie many of these processes. Developing reagents that can selectively alter the expression level of any desired gene has been a goal of both scientists and clinicians for years. Historically, the most common approach ...

    SBIR Phase II 2010 Department of Health and Human Services
  10. Nutritional Intervention for Age-Related Muscular Function and Strength Losses

    SBC: MTI Biotech Incorporated            Topic: NIA

    DESCRIPTION (provided by applicant): Sarcopenia, defined as age related loss of muscle mass and muscle function and strength, is very prevalent among the elderly. Sarcopenia is one of the largest public health problems facing a rapidly increasing, aging population in the United States and leads to increased incidence of falls, fractures and associated morbidities. Previous observations from our la ...

    SBIR Phase I 2010 Department of Health and Human Services

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