Award Data

Based on encouraging Phase I feasibility results, we propose developing a novel gene therapy approach to promote guided vascular regeneration in treating extremities after traumatic injury. Our approach is to provide thread-like implants comprised of aligned nanofibrillar collagen scaffolds loaded with Hepatocyte Growth Factor (HGF) vectors (e.g., HGF DNA plasmid, modified mRNA) designed to enhanc ...

The ready availability of universal donor plasma to rapidly treat massively bleeding hospital trauma patients and warfighters with combat casualties is a key element of current recommendations for trauma resuscitation, yet universal AB donor plasma is rel

Based on our success in developing the world first commercial high energy femtosecond fiber laser system and our leading proprietary technology development in ultrashort pulsed fiber laser material processing, PolarOnyx proposes, for the first time, a compact high energy fiber laser based smart wound healing tool to meet with the requirement of this DHP solicitation. It includes a high energy fs f ...

Between Operation Iraqi Freedom, Operation Enduring Freedom, and Operation New Dawn, the total number of U.S. Casualties (those Wounded in Action) has exceeded 52,000 as of January 30, 2015. These numbers point to the fact that active warfighters in the battlefield are almost constantly exposed to the threat of external penetrating wounds. The goal of combat wound care is to protect open wounds u ...

Surgical simulations aiming to support surgeon practices and medical education have attracted enormous research effort over the last two decades. However, the physical reality, especially on simulating aggregated tissue interaction, is still unsatisfactory. In this proposed work, an open source surgery simulation framework, SoFMIS, will be utilized and enhanced with tissue interaction models to a ...

In Phase I of KEPLER, we will demonstrate how customizing extraction techniques for knowledge base population will allow us to capture and reason with the rich semantics of events and actions. We will demonstrate (1) how to extract event parameters, event construals, and inter-event relations which can form several composite event constructs; (2) how to reason with a KB focusing on events by combi ...

Electron spin resonance (ESR) spectroscopy is a widely used forensic technique to study post-nuclear debris fields, radiation-induced damage in solids and many other phenomena surrounding the interaction of radioactivity with solid matter. ESR spectroscopy is also used to analyze dust, smoke and other gaseous samples. Our Micro-ESR technology has the benefit of being an extremely robust, lightweig ...

This program develops innovative technology for chip-to-chip and intra-chip interconnects that will operate in extreme radiation environments.There is considerable development in chip-to-chip and intra-chip interconnects in the commercial market.This program will leverage these advancements and demonstrate their applicability to satellite and unmanned avionic vehicles (UAV) platforms.

The capabilities of modern x-ray light sources have opened up new areas in the study of the temporal evolution of complex materials under dynamic loading, which require detectors with high sensitivity, wide dynamic range at frame rates approaching the bunch repetition rates of modern light sources and detection at x-ray energies above 20keV.However, the capability to do such research is limited by ...

Coupling high intensity and high flux x-ray capabilities with impact drivers (lasers, gas guns, etc.) provide opportunity for directly probing material deformation mechanisms under extreme loading conditions. Limitations in existing x-ray detection capabilities prevent complete mapping of the temporal evolution of dynamic material events under fast loading rates. X-ray energy detection > 20 keV is ...