Award Data

Based on encouraging Phase I feasibility results, we propose developing a novel gene therapy approach to promote guided vascular regeneration in treating extremities after traumatic injury. Our approach is to provide thread-like implants comprised of aligned nanofibrillar collagen scaffolds loaded with Hepatocyte Growth Factor (HGF) vectors (e.g., HGF DNA plasmid, modified mRNA) designed to enhanc ...

The ready availability of universal donor plasma to rapidly treat massively bleeding hospital trauma patients and warfighters with combat casualties is a key element of current recommendations for trauma resuscitation, yet universal AB donor plasma is rel

Based on our success in developing the world first commercial high energy femtosecond fiber laser system and our leading proprietary technology development in ultrashort pulsed fiber laser material processing, PolarOnyx proposes, for the first time, a compact high energy fiber laser based smart wound healing tool to meet with the requirement of this DHP solicitation. It includes a high energy fs f ...

Between Operation Iraqi Freedom, Operation Enduring Freedom, and Operation New Dawn, the total number of U.S. Casualties (those Wounded in Action) has exceeded 52,000 as of January 30, 2015. These numbers point to the fact that active warfighters in the battlefield are almost constantly exposed to the threat of external penetrating wounds. The goal of combat wound care is to protect open wounds u ...

Surgical simulations aiming to support surgeon practices and medical education have attracted enormous research effort over the last two decades. However, the physical reality, especially on simulating aggregated tissue interaction, is still unsatisfactory. In this proposed work, an open source surgery simulation framework, SoFMIS, will be utilized and enhanced with tissue interaction models to a ...

In the present-day network of high-voltage overhead transmission lines, segments of cable are joined by a crimp splice joint, in which the locking of strands in the two cables relies upon a serrate sleeve that is crushed into the cable. The transmission line heats in temperature as it carries electric power, and the span of cable between towers stretches each time the temperature of the cable is i ...

Advances in electric drive vehicles (EDVs), including hybrid electric (HEV), plug-in hybrid (PHEV) and electric (EV) vehicles, are key to reduce U.S. foreign oil dependence and greenhouse gas emissions. Battery technologies are critical to the development of EDVs. State-of-the-art battery technologies fall far short of the energy density requirements for most automotive and other commercial applic ...

Accelerator magnets that are currently being used in high-­‐energy physics experiments are limited to a maximum magnetic field of less than 20 T because superconductivity in the low-­‐ temperature superconductors from which the magnets are constructed breaks down at higher fields. The next generation of accelerator magnets needs to be made from high-­‐temperature superconducting magnet ca ...

Today's cryogenic pumping consist of two vastly different options. The most common, are centrifugal turbopumps with an impeller-inducer combination which rely on high impeller speeds to create pressure. While the high speed makes them more compact, it also limits life. In addition, the impeller design leads to high flow dependence on differential pressure. Also, impellors can have issues handling ...

The DOE High Energy Physics (HEP) program seeks to develop advanced accelerator technologies that reduce overall machine size and cost, and also to develop new concepts and capabilities that further scientific and commercial goals beyond HEP’s discovery science mission. Superconducting Radiofrequency ccelerators consume much less power than room temperature accelerators, so can one day replace ...