Award Data

ABSTRACT Human prion diseases are infectious and invariably fatal neurodegenerative diseases including sporadic Creutzfeldt Jakob disease sCJD the most common form and variant CJD vCJD which is associated to consumption of cattle meat infected by bovine spongiform encephalopathy Currently there is not sensitive objective and non invasive biochemical diagnosis for these diseases and even ...

Sepsis is the leading cause of deaths in US hospitals contributing to or causing of all US hospital deaths and is the most expensive condition treated in US hospitals costing more than $ billion annually More than million blood culture bottles are produced annually with a market size greater than $ B in the US and EU alone The two year phase II period spanned February to F ...

Traumatic brain injury TBI is an acquired neurological disorder that can cause long lasting disability with limited treatment options Therefore preventative strategies must be emphasized in high risk activities to reduce the individual and societal burden of this pervasive injury Bicycle activities account for of all sports related TBI with over annual injuries in the US In an e ...

Pelvic organ prolapse POP is a highly prevalent condition affecting over of women in the US during their lifetimes Urinary incontinence UI affects an estimated of women Both POP and UI are more common in women than in men and their prevalence is increased with age Some loss of utero vaginal support occurs in most adult women however the true etiology of prolapse and differences se ...

Abstract The goal of this project is to utilize cytomegalovirus CMV vectors to develop a therapeutic vaccine against Trypanosoma cruzi the causative agent of Chagas disease Although the most common transmission route is by a triatomine bug vector known as the kissing bug Chagas disease is also spread vertically from mother to child and along blood born routes such as organ transplant and tr ...

Native American Cancer Initiatives Inc NACI is a woman owned minority American Indian business with fewer than three full time equivalent employees This for profit company founded in has the mission to provide technical assistance and products to communities patients researchers academicians universities research institutions and professionals on Native Americans cultural iss ...

Project Summary The long term goal of this project is to develop validate and commercialize an assay for improved analysis of C orf a gene on chromosome that is linked to frontotemporal dementia FTD and amyotrophic lateral sclerosis ALS Expansion of a guanine and cytosine rich hexanucleotide repeat GGGGCC in the non coding region of C orf is associated with of familial ALS Th ...

PROJECT SUMMARY Alcohol addiction and disorders associated to excessive alcohol use are a serious public health problem in the United States and in other parts of the world Current pharmacotherapies for the treatment of these disorders show limited efficacy Preclinical and clinical findings point to nicotinic acetylcholine receptors nAChRs as an alternative promising target for the developmen ...

Project Summary All cancer patients live with the possibility that their cancer will recur and many patients develop secondary cancers as a result of treatments used for their original cancer This project addresses the problem of drug resistance and disease recurrence in cancer by leveraging unique single nanoparticle techniques to identify rare often hidden drug resistant cells in leukemia ...

Despite the recent development of novel therapeutic approaches no curative treatment is available for advanced stage melanoma with year survival below Targeted therapy is one of the most promising therapeutic strategies to the treatment of cancer and is a key component of precision medicine which aims to individualize cancer treatment for a given patient IL RA an oncogenic isoform o ...