Award Data

ABSTRACTTechnology to deliveron demandmolecules that bind targets or catalyze reactions of choice has been a goal of chemistry foryearsEven todaytheory is inadequate to support de novo design of receptors having useful affinity or catalysts having useful turnoverThusmany have sought to create those catalysts on a DNA or RNAcollectivelyxNAusing the Darwinism to these biomolecules to evolveunder lab ...

ABSTRACT Current clinical photodynamic therapy PDT is an effective cancer treatment that is non invasive and low cost but it has yet to become a mainstream frontline treatment The clinical efficacy of PDT in solid tumors depends on significant accumulation of the photosensitizer PS at the tumor site availability of oxygen near the photosensitizer and effective dosing of the drug light c ...

Alzheimer s disease AD is a multifactorial heterogeneous and enormously complex disorder characterized by progressive intellectual deterioration Although remarkable advances have been made in unraveling the biological basis of the disease in the last two decades that immense knowledge has not been translated in to successful therapy With the failure of secretase inhibitors at the clinical tr ...

ABSTRACT SUMMARY The outcome of this phase project will yield a turnkey system for spectroscopy polarimetry in the terahertz THz frequency range designed to support development of new drugs This system will directly probe protein vibrations using polarized terahertz radiation allowing researchers to rapidly characterize intramolecular vibrations which will help identify sites on ...

Abstract PTI is developing PTI DX a novel quantitative blood based diagnostic candidate for Alzheimerandapos s disease AD A non invasive and inexpensive AD diagnostic is sorely needed particularly one with the ability to detect early pathological changes that precede cognitive symptoms PTI DX measures the ratio of two protein fragments in plasma and is a companion diagnostic biomark ...

PUBLIC ABSTRACT This project in response to announcement HLS describes a development program for CARSKNKDC CAR a synthetic cyclic peptide that selectively targets diseased pulmonary vascular endothelium and enhances the therapeutic effect of vasodilator therapies for the treatment of pulmonary hypertension PH PH is a disorder of elevated pulmonary vascular resistance characterized by ...

ABSTRACT Pediatric injury is the leading cause of child mortality and acquired disability in the United Statesaffectingmillion children annuallyAmong school age children alonemore thanmillion are treated in Emergency Department or admitted to the hospital annually for injuryincurring billions in medical and work loss costs each yearAfter hospital dischargemany injured children experience pain that ...

PROJECT ABSTRACT Short bowel syndromeSBSis a major clinical problem affecting newbornschildren and adultsfor which there is currently no known cureThe disorder results from the functional or anatomic loss of extensive segments of small intestine rendering the intestinal absorptive capacity severely compromisedSBS is clinically defined by malabsorptiondiarrheasteatorrheafluid and electrolyte distur ...

The S-351 mini-sub is a prototype of the Dry Combat Submersible (DCS). This prototype was established as a means of risk reduction prior to a full commitment to the DCS program. Both of these platforms have an operational need to transit with minimum operator fatigue safely to a pre-defined point and covertly deploy and retrieve SEALS. To meet these operational needs, these platforms require upgra ...

AbstractThe treatment of large cartilage lesions is a difficult clinical problem for which there are few good solutionsLeft untreatedthese lesions tend to degenerate to chronic pain and osteoarthritisOAultimately requiring a total joint replacementFor patients suffering from knee OAandin particularunicompartmental OAunicondylar knee arthroplastyUKAis an available first line treatment option that p ...