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The Award database is continually updated throughout the year. As a result, data for FY21 is not expected to be complete until September, 2022.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Metal Digital Direct Manufacturing (MDDM) for Close-Out of Combustion Chambers and Nozzle Fabrications

    SBC: Keystone Synergistic Enterprises, LLC            Topic: T1204

    This NASA sponsored STTR project will investigate methods for close-out of large, liquid rocket engine, nickel or stainless steel nozzle, coolant channels utilizing robotic laser and pulsed-arc additive manufacturing (AM)methods. Structural jacket to coolant channel land area interface strength will be quantified and metallurgical characterization completed. Process optimizations will be conducte ...

    STTR Phase II 2017 National Aeronautics and Space Administration
  2. STTR Phase I: Re-engineered skin bacteria as a novel topical drug delivery system

    SBC: Azitra Inc.            Topic: BM

    This STTR Phase I project aims to establish the viability of a drug delivery platform that employs an engineered strain of Staphylococcus (S.) epidermidis, a common skin commensal bacterium, that can secrete therapeutic proteins of interest for the ultimate goal of treating skin disease. An ointment with an inoculum of such bacteria could be infrequently applied to skin, providing constant, low-co ...

    STTR Phase I 2017 National Science Foundation
  3. Receptors, Ligands, and Catalysts on Demand using Expanded Genetic Alphabets

    SBC: FIREBIRD BIOMOLECULAR SCIENCES LLC            Topic: 100

    ABSTRACTTechnology to deliveron demandmolecules that bind targets or catalyze reactions of choice has been a goal of chemistry foryearsEven todaytheory is inadequate to support de novo design of receptors having useful affinity or catalysts having useful turnoverThusmany have sought to create those catalysts on a DNA or RNAcollectivelyxNAusing the Darwinism to these biomolecules to evolveunder lab ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Demonstration of the technological capability for production of neutron-focusing nickel mirrors

    SBC: ELECTROFORMED NICKEL, INC.            Topic: 08a

    Neutron scattering is one of the most useful methods of studying the structure and dynamics of matter. Therefore, a number of new large neutron facilities have recently being constructed, upgraded or planned around the world. Examples include the new, 1.4 billion-dollars Spallation Neutron Source (SNS) at DoE’s Oak Ridge National Laboratory (ORNL) and upgrades of ORNL’s High-Flux Isotope React ...

    STTR Phase I 2017 Department of Energy
  5. Identification of Small Molecule Amyloid Beta Peptide Reducing Agent

    SBC: Smart Biomolecules, Inc.            Topic: NIA

    Alzheimer s disease AD is a multifactorial heterogeneous and enormously complex disorder characterized by progressive intellectual deterioration Although remarkable advances have been made in unraveling the biological basis of the disease in the last two decades that immense knowledge has not been translated in to successful therapy With the failure of secretase inhibitors at the clinical tr ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Turnkey THz Spectroscopy Polarimetry System for Pharmaceutical Applications

    SBC: Microtech Instruments, Inc.            Topic: 400

    ABSTRACT SUMMARY The outcome of this phase project will yield a turnkey system for spectroscopy polarimetry in the terahertz THz frequency range designed to support development of new drugs This system will directly probe protein vibrations using polarized terahertz radiation allowing researchers to rapidly characterize intramolecular vibrations which will help identify sites on ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. HLS Cyclic CAR peptide a targeted therapy for pulmonary hypertension

    SBC: VASCULAR BIOSCIENCES, INC.            Topic: NHLBI

    PUBLIC ABSTRACT This project in response to announcement HLS describes a development program for CARSKNKDC CAR a synthetic cyclic peptide that selectively targets diseased pulmonary vascular endothelium and enhances the therapeutic effect of vasodilator therapies for the treatment of pulmonary hypertension PH PH is a disorder of elevated pulmonary vascular resistance characterized by ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Tissue Engineered Intestine

    SBC: NANOFIBER SOLUTIONS LLC            Topic: 300

    PROJECT ABSTRACT Short bowel syndromeSBSis a major clinical problem affecting newbornschildren and adultsfor which there is currently no known cureThe disorder results from the functional or anatomic loss of extensive segments of small intestine rendering the intestinal absorptive capacity severely compromisedSBS is clinically defined by malabsorptiondiarrheasteatorrheafluid and electrolyte distur ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. STTR Phase I: Development of a Machine Learning Platform to Predict Surgical Complications

    SBC: Kelahealth Inc.            Topic: SH

    The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to create a personalized, precision-based practice paradigm for surgery that improves surgical outcomes and reduces the cost of healthcare. This paradigm utilizes individual patient characteristics with machine-learning algorithms to accurately predict the risk of post-surgical complication ...

    STTR Phase I 2017 National Science Foundation
  10. NONA Repair of Composite Structures

    SBC: Cornerstone Research Group, Incorporated            Topic: T1202

    Supporting aerospace mission readiness, a system is needed that allows for composite repairs without the current roadblocks imposed by ovens, autoclaves, and expensive tooling. Cornerstone Research Group (CRG), its subsidiary NONA Composites, and the University of Dayton Research Institute (UDRI) presents NASA with the opportunity to obtain a rapid and robust method for on-site composite structura ...

    STTR Phase II 2017 National Aeronautics and Space Administration
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