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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Novel Circulating RNA-based Markers as Diagnostic Biomarkers of Infectious Diseases

    SBC: CFD RESEARCH CORPORATION            Topic: CBD18A001

    In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens,whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial andalphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable and ...

    STTR Phase I 2018 Department of DefenseOffice for Chemical and Biological Defense
  2. Host-Targeted Antiviral Drugs Providing Rapid, Scalable, Stable, Broad-Spectrum MedicalCountermeasure Against Marburg Virus

    SBC: EVRYS BIO LLC            Topic: CBD18A002

    In a pandemic or exposure to weaponized Marburg virus the morbidity, mortality and social unrest that will ensue before vaccines orMilitary operating on foreign soil as well as to the population of the US Homeland. Practically all threat agents of biological origin (except forcertain non-proteinaceous toxins, typically produced by marine organisms and fungi) have their structure and vital function ...

    STTR Phase I 2018 Department of DefenseOffice for Chemical and Biological Defense
  3. Human monoclonal antibodies as countermeasures for T-2 mycotoxin

    SBC: ABZYME THERAPEUTICS LLC            Topic: CBD152003

    Mycotoxins are fungal toxins to which exposure frequently results in incapacitation or even in death. Natural outbreaks of mycotoxin poisoningare common worldwide. Due to its physical-chemical properties, high toxicity and relative ease to produce, mycotoxin T-2 is classified as apotential biological warfare agent. Currently there are no FDA approved medical countermeasures available for T-2 mycot ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  4. Exploiting Natural Products-Based Therapeutics for Aflatoxin Mitigation

    SBC: CFD RESEARCH CORPORATION            Topic: CBD152003

    Aflatoxins are a paradigm among fungal produced mycotoxins that are present in food supplies and are strongly associated with increased risk forthe development of hepatocellular carcinoma. Currently, there are no known countermeasures that can selectively mitigate aflatoxin toxicity andthe available options are only symptomatic treatments. To meet this challenge, we propose to harness the microbio ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  5. Adjustable Focus Lenses for Respiratory Protection

    SBC: VOXTEL, INC.            Topic: CBD152001

    A low-cost, adjustable optical-correction technology will be developed for integration with AVON M50 respiratory protective masks, allowing forfast, adjustable vision correction. Variable-focus lenses will be designed using 3D freeform gradient index materials, which allow both opticalpower and geometric and chromatic aberrations corrections to be achieved in planar films. A Phase I prototype will ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  6. Producing Novel Biosynthetic Therapeutics from Extreme Microbiomes

    SBC: iXpressGenes, Inc.            Topic: CBD152004

    Environmental DNA from three extreme samples will be isolated, cloned into a fosmid library (5760 clones) for sequencing. The sequencing datawill cover ~ 240 Megabases and will be assembled into contigs long enough (~ 40 Kilobases) to represent potential biosynthetic gene clusters(BGCs). This data will be compared to BGC databases looking for homology to antibiotic targets of DoD interest and with ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  7. Durable Aerosol and Liquid Repellent coatings

    SBC: HYGRATEK LLC            Topic: CBD161002

    Chemical and biological (CB) warfare agents are a serious threat to our soldiers and national security. Different warfare agents and microbes may be delivered using solids (powders, particulates, ice crystals), hydrosols (air borne liquid droplets), or aerosols (air-born particulates). Solids, hydrosols, or aerosols can penetrate, accumulate, and transport through both porous and non-porous surfac ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  8. Single domain antibodies as medical countermeasures for viral induced encephalitis

    SBC: ABZYME THERAPEUTICS LLC            Topic: CBD161004

    Alphavirus infection, which may cause encephalitis and death, are recognized as potential biological warfare agents. There are no approved medical countermeasures against diseases caused by Alphaviruses. In this project, thermostable single domain antibodies capable of crossing the blood brain barrier (BBB) and neutralizing encephalitic viruses will be developed using Abzymes proprietary in vivo S ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  9. Selection of blood-brain barrier penetrating single domain antibodies as medial countermeasures for viral induced encephalitis

    SBC: GUILD ASSOCIATES INC            Topic: CBD161004

    Alphaviruses pose significant risks to warfighters where encephalitic virus infection can lead to death. There is no effective treatment for alphavirus induced encephalitis and countermeasures are of high importance. Single domain antibodies (sdAb) are low molecular weight engineered antibody fragments composed of a single heavy-chain variable domain which have proven easier to manipulate and re-e ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
  10. Protective Mask Sizing App

    SBC: CFD RESEARCH CORPORATION            Topic: CBD161005

    Typical procedures for respirator masks sizing and protective fit test are time-consuming and user intensive, requiring taking anthropometric measurements of the wearer, sampling the wearers breathing zone and the use of specialized tools and equipment. The proposed software app aims to quickly, accurately and automatically perform respirator mask sizing and predict protective fit using only 2D im ...

    SBIR Phase I 2016 Department of DefenseOffice for Chemical and Biological Defense
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