Award Data

SUMMARY Sepsis is a clinical syndrome that complicates severe infectionSepsis remains the leading cause of morbidity and mortality in critically ill patientsThere are no specific FDA approved medicines for the treatment of sepsisCurrent concepts of the pathophysiology of sepsis suggest that organ failure and mortality in sepsis are caused by inappropriate regulation of the immune systemThis manife ...

A key application of the technological breakthrough associated with decreased cost of DNA sequencing is metagenomics. Metagenomics is the process of sequencing DNA from whole ecosystems, rather than individuals or cultures. This approach has the potential to allow the dissection of microbial ecosystems in biofuel producing agricultural land, toxic contaminated sites and hydrocarbon recovery enviro ...

DESCRIPTION (provided by applicant): The goal of this proposal is to develop a drug that will be therapeutic for obesity and diabetes and improve exercise tolerance. Obesity, diabetes and exercise are inextricably linked such that an agent that improves exercise tolerance or prevents obesity or the development of diabetes will likely have a therapeutic role in all three conditions. Obesity is a gl ...

The STTR topic T5.01 envisions Autonomous Communications Systems (ACS) that can be aware of RF environment and the network status and learn from experience to enhance adaptability to nominal/anomalous conditions, self-reconfigure network connections, dynamically maximize performance in response to sensed conditions and mitigate system-level effects of outages and interference. In Phase II, Bluecom ...

DESCRIPTION (provided by applicant): Osteoarthritis (OA) is the leading cause of chronic disability in the United States. A clinical goal in the treatment and prevention of OA is to develop replacement cartilage using tissue engineering (TE) technologies. Although TE cartilage presently lacks the mechanical stability of native cartilage, studies have demonstrated that mechanical stability can be e ...

Information Systems Laboratories (ISL) and Florida Atlantic University (FAU) propose to develop and test a system that uses existing signal processing algorithms coupled with innovative construction technology developed ISL under our E-Field sensor programs and FAU under UUV programs. The Challenge is to develop a small system package with the capability to intercept active threat emissions early ...

DESCRIPTION provided by applicant The overall goal of this project is to demonstrate the ability of our acute myocardial infarct selective paramagnetic contrast agent Gadolinium ABE DTTA to differentiate between acute and chronic infarcts in a reliable manner using contrast enhanced magnetic resonance imaging ceMRI In our Phase I data we have shown that Gd ABE DTTA exclusively highlight ...

The focus of this STTR program is the development and maturation of a novel, room-temperature process to fabricate multi-layer metal-polymer (including PVDF and other smart materials) composites in an additive approach. This overcomes the limitation arising from the large temperature difference between metal and polymer manufacturing processes, and presents a new technology for additive manufactur ...

Synthetic scenario-based training of Navy personnel in the use of Navy SIGINT/IO systems has helped to reduce training costs, and it has enabled the personnel to be trained in an environment that sufficiently approximates real-world situations that could not otherwise be accomplished within the class room. However, scenario development is highly complex and involves a great deal of human effo ...

Nanoscale infrared detectors are emerging as a potentially powerful alternative to traditional infrared detector technologies. The University of New Mexico has developed dots in a double well (DDWELL) quantum dot infrared photodetectors which have a spectral responsivity that can be tuned by controlling the bias voltage applied. In this Phase II effort, Polaris Sensor and UNM would fabricate a g ...