Award Data

The drug R&D cycle is long and very expensive. In many ways, this status quo can no longer be sustained. One of the reasons for such great cost is that the vast majority of drug candidates are screened out at the stages of animal and human trials. More efficient methods of testing of drugs at the stage of ex-vivo studies, which are substantially less expensive than animal and human testing cyc ...

We will employ the very latest methods in nanotechnology to realize vastly improved CO2 scrubbing efficiency in closed cycle underwater breathing apparatuse(UBA). Our system will occupy minimal volume, will be simple in design and will employ benign nano-particles as the CO2 active scrubbing material. Due to the design, CO2 uptake will be maximized and breathing flow resistance will kept at a mi ...

The dynamics of nano-size interactions of metal hydroxide nanoplatelets is a new field of material science. Initial research conducted by Aqua Resources and the Department of Defense, offers the promise of an innovative means of effectively defending against Chemical/Biological (CB) warfare agents in a cost effective manner without the attendant residues and long-term damage associated with tradit ...

A need exists for a new environmental situational awareness sensor with multi-spectrum camouflage that is extremely small (90g) and capable of measuring with aviation-grade accuracy: wind speed/direction, horizontal visibility, sky condition, cloud heights, temperature, dewpoint, barometric pressure, precipitation and CBRN contamination. There exists a strong desire to support a variety of commun ...

GMECI proposes to combine existing commercial template matching and feature extraction algorithms with existing military EOIR sensor technology, to automatically highlight in real time friendly forces on existing displays. The proposed technology, Blue force Designated Optical Templates (BlueDOTs) will allow automatic computer recognition and highlighting to discern among individual, customized lo ...

Current drug discovery and development programs are severely limited by the expensive animal trials and oversimplified in vitro models. Results obtained from the in vitro models are not predictive of in vivo toxicity owing to significant difference in testing from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device for quantitati ...

Molecular biology techniques allow generating combinatorial libraries of large number of enzyme variants. However, there is currently no technology available for screening the enzyme libraries for identifying variants with improved activity for the substrate. We propose to develop a novel, microfluidic, high-throughput platform for determining kinetic constants of enzyme variants and identifying v ...

PCP Ammunition Company will deliver a family of Lightweight Advanced Polymer Sub-Sonic Ammunition. We will do this by adapting our current family of calibers by decreasing the internal volume and shape of the case to match the optimal performance requirements of the cartridges. This will result in a sub-sonic ammunition that is lightweight, clean burning (due to the internal volume and dimension ...

PCP Ammunition Company will research the design and development of Lightweight .50 caliber precision ammunition under this SBIR Phase I contract. PCP will concentrate our efforts on several separate criteria in order to improve upon the current .50 caliber round by utilizing PCP"s current lightweight polymer .50 caliber case. First, we will compare the performance of the current round agains ...

Protein manufacturing is of paramount importance to chemical and biological defense applications. High-throughput protein purification is a critical need for rapidly scaling the target protein product. Existing purification methods primarly rely on synthetic-resin based chromatography, which is time-consuming, labor-intensive, expensive, and consequently, ill-suited for developing rapid countermea ...