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Chemical warfare agents such as the lethal nerve agent soman are a major source of risk to military personnel. Currently, pyridostigmine bromide (PB) is the only FDA-approved pretreatment to counteract the effects of soman. The rationale behind PB administration is that it acts as a “temporary” inhibitor of AChE. This precludes nerve agents from irreversible inactivation of AChE, thereby mitig ...

CMC Pharmaceuticals, Inc. (Cleveland, OH) is proposing developing a stable, combination product of two small molecule drug candidates as a counter measure to chemical warfare nerve agents (NA). The combination product is expected to exploit complementary pharmacological profiles for optimal muscarinic receptor blockade and anticholinergic activity within the peripheral and central nervous system. ...

To address the Chemical and Biological Defense (CBD) need for a field-portable mass spectrometer for small molecule drugs in clinical samples, Physical Optics Corporation (POC) proposes to develop a new FiEldable DRug Mass Analysis (FERMA) system based on a combination of portable mass spectrometry technology with laser desorption/ionization for use with aqueous clinical samples. The FERMA system ...

We propose a novel two-dimensional mass spectrometry (2D-MS) technique based on ion trap arrays to identify illicit and designer drugs. This approach will give an unprecedented multiplex advantage for miniature mass spectrometry, allowing novice field technicians to rapidly identify drugs affecting the central nervous system based on both the m/z ratio and fragmentation pattern of an ion. Towards ...

In order to meet Defense Health Agency’s need for rapid confirmation and evaluation of open globe injuries, to allow for appropriate initial triage, evacuation, and treatments, ChromoLogic LLC (CL) proposes to develop an Ocular Penetrating/Perforating inj

Most standard-of-care tools and techniques for evaluating neck disorders are subjective, unreliable, and do not provide actionable information for providers, payers, and organizations to deliver efficient and effective care. This lack of objective neck he

Care for the wounded Warfighters in austere and remote settings makes medical knowledge, skills and efficiency of the military medical professional paramount. For wounds that extend deep into internal anatomy, proper visualization of internal anatomy can

We propose development of an AR system that allows the medical personnel to visualize the internal anatomy of a patient by projecting relevant anatomical information onto the patient directly into the field of view (FOV) of the medic. With no medical imag

The purpose of the MEDIC (Medic’s Enhanced Diagnostic Imaging Companion) system is to provide combat medics, via Augmented Reality (AR), a digitally-superimposed avatar representing the internal anatomy of their Warfighter patient. Phase I of this SBIR p

We propose to develop SmartPatient BOT driven by a continuous learning Natural Language Processing (NLP) Engine which can understand medical learner's questions in a natural conversation mode and provide responses from the medical simulator instead of int