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Chemical warfare agents such as the lethal nerve agent soman are a major source of risk to military personnel. Currently, pyridostigmine bromide (PB) is the only FDA-approved pretreatment to counteract the effects of soman. The rationale behind PB administration is that it acts as a “temporary” inhibitor of AChE. This precludes nerve agents from irreversible inactivation of AChE, thereby mitig ...

CMC Pharmaceuticals, Inc. (Cleveland, OH) is proposing developing a stable, combination product of two small molecule drug candidates as a counter measure to chemical warfare nerve agents (NA). The combination product is expected to exploit complementary pharmacological profiles for optimal muscarinic receptor blockade and anticholinergic activity within the peripheral and central nervous system. ...

To address the Chemical and Biological Defense (CBD) need for a field-portable mass spectrometer for small molecule drugs in clinical samples, Physical Optics Corporation (POC) proposes to develop a new FiEldable DRug Mass Analysis (FERMA) system based on a combination of portable mass spectrometry technology with laser desorption/ionization for use with aqueous clinical samples. The FERMA system ...

We propose a novel two-dimensional mass spectrometry (2D-MS) technique based on ion trap arrays to identify illicit and designer drugs. This approach will give an unprecedented multiplex advantage for miniature mass spectrometry, allowing novice field technicians to rapidly identify drugs affecting the central nervous system based on both the m/z ratio and fragmentation pattern of an ion. Towards ...

To address the CBD’s need for real-time analytical technology for multicomponent vapor identification and quantification, Physical Optics Corporation (POC) proposes to continue the development of a new Photoacoustic Gasses Optical Detector and Analyzer (PAGODA) autonomous, network-enabled photoacoustic spectrometer (PAS) for the correlation, analysis, and identification of measured spectra. In t ...

A program to develop a compact, MLA-based, LWIR, full-motion-video hyperspectral imager for chemical detection is proposed. The proposed Hyperspectral Chemical Imaging Sensor (HyCIS) builds upon Surface Optics’ real-time hyperspectral imaging activities, including our 3D full-motion-video spectral imaging (FMV-SI) technology and our MIDIS hyperspectral image processor. Simultaneously sampling 16 ...

SA Photonics is please to submit the proposal for the HawkEye compact LWIR hyperspectral imaging system. HawkEye leverages SA Photonics previous visible, SWIR, and LWIR programs to result in a compact, hand held, battery operated hyperspectral imager in a low cost design approach. Furthermore, HawkEye will leverages SA Photonics expertise in warfighter body worn equipment and ground troop personal ...

Rapid innovation in computer-mediated communication (e.g., social media) has created new channels for the spread of information. The proposed work will integrate Advanced Brain Monitoring’s neurological and physiological metrics (e.g., EEG, ECG, eye-tracking) with Cubic Intific Corporation’s Social Media Analytic Replication Toolkit (SMART) to yield a unified framework for analyzing informatio ...

Future TBCC propulsion systems, in addition to incorporatingvariablegeometricalenginefeatures,will require controllingtheengine duringits transient mode,as wellas,managingaerodynamicand thermal limits of thesystem over theentireflight range. Theimportantchallenges of TBCC enginesareto establish astablemodetransition process whilemaintaining propulsion system performanceand operability, perform ast ...

The proposal discusses the possible implementation of the high power density high voltage unit that can satisfy technical requirements of the unit defined in the DARPA SBIR Topic# SB171-010 (Ultra-Compact Power Conditioning System for High Power RF Transmitters). Paper summarizes the results of the work that was performed by CPE during Phase I in 2017. The electrical design of all critical power s ...