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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. An Interactive Informed Consent Program for Cardiac Procedures

    SBC: ARCHIE MD INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Informed consent has become an essential component of the doctor-patient interaction. The informed consent process requires that patients not only be given information about proposed medical treatment, but that it be presented in an understandable way so the patient can make meaningful choices about medical alternatives. At the heart of the inf ...

    STTR Phase I 2007 Department of Health and Human ServicesNational Institutes of Health
  2. CAN CD 133 CELLS PREVENT HYPOXIA DRIVEN RETINAL NEOVASCULARISATION IN A RODENT MO

    SBC: Arteriocyte, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The clinical significance of ocular angiogenesis is enormous, due to the fact that in the western hemisphere, retinal neovascularization resulting from diabetic retinopathy is the most common cause of new blindness in young patients, and choroidal neovascularization (CNV) resulting from AMD is the chief cause of severe and irreversible loss of vision in elderly ...

    STTR Phase I 2007 Department of Health and Human ServicesNational Institutes of Health
  3. Stem Cells for Neonatal Hypoxic-Ischemic Brain Injury

    SBC: ATHERSYS, INC.            Topic: N/A

    DESCRIPTION: The specific objective of this STTR Phase II research and development project is to provide an optimized cellular therapy regimen for treating hypoxic-ischemic (HI) injury and its related outcomes in neonates. Pre- clinical studies performed in a rat pup model of HI injury as part of the funded Phase I STTR grant, point to benefit when Multipotent Adult Progenitor Cells (MAPC), a plur ...

    STTR Phase II 2007 Department of Health and Human ServicesNational Institutes of Health
  4. Long distance nerve regeneration via processed allografts in a caprine model

    SBC: Axogen Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Every year in the US, several million people suffer serious peripheral nerve injury. Injuries to the peripheral nervous system (PNS) are a major source of disability, impairing the ability to move muscles or to feel normal sensations. To treat these problems, more than one million procedures were performed in the US in 2002, totaling more than $10 billion in me ...

    STTR Phase I 2007 Department of Health and Human ServicesNational Institutes of Health
  5. User Adaptation of AAC Device Voices

    SBC: BIOSPEECH INC            Topic: N/A

    DESCRIPTION (provided by applicant): A wide range of individuals cannot communicate by voice. Voice enabled Augmentative and Alternative Communication (AAC) devices are often the only channel available by which these individuals can communicate. While many voice enabled AAC devices are currently available, they lack the important ability to generate customized speech that mimics aspects of the use ...

    STTR Phase I 2007 Department of Health and Human ServicesNational Institutes of Health
  6. HUCBC modulation of Alzheimer-like pathology and behavioral changes

    SBC: SANERON CCEL THERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Modulation of the inflammatory cascade by several diverse strategies including A immunization, non-steroidal anti-inflammatory drug (NSAID) administration, and manipulation of microglial activation states have all been shown to reduce Alzheimer disease (AD)-like pathology, and cognitive deficits in AD transgenic mouse models. Our recent study demonstrated ameli ...

    STTR Phase I 2007 Department of Health and Human ServicesNational Institutes of Health
  7. Side-by-side comparison of blood-brain barrier models

    SBC: CLEVELAND MEDICAL DEVICES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The blood-brain barrier (BBB) is crucial for complex issues such as drug delivery, pathogenesis of chronic neurological diseases involving BBB dysfunction (e.g., brain tumors, ischemia, hypoxia, brain edema, multiple sclerosis, and meningitis) and issues related to bio-defense. Since the BBB selectively (by specific transport mechanisms) excludes most blood-bor ...

    STTR Phase II 2007 Department of Health and Human ServicesNational Institutes of Health
  8. Assessing Suicide Risk in the ED: Web-based MD training

    SBC: CME DEVELOPMENT GROUP, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Over the past twenty-five years, there has been a sharp rise in the number of children and adolescents presenting to emergency departments (EDs) for psychiatric issues. Given that youth mental health issues account for 1.6% - 5.0% of all ED visits, and that Emergency Medicine physicians are the first to interact with these youth, the assessment of psychiatric i ...

    STTR Phase II 2007 Department of Health and Human ServicesNational Institutes of Health
  9. Designed Antimalarial Agents Overcoming Chloroquine-Resistance

    SBC: DESIGNMEDIX, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The intent of the work presented in this proposal is to counter the worldwide health problem brought on by the spread of chloroquine-resistant malaria. To address the need for an orally available and inexpensive replacement drug, we have developed a novel class of molecules called "reversed chloroquines" (RCQs) which act against both chloroquine-resistant and c ...

    STTR Phase I 2007 Department of Health and Human ServicesNational Institutes of Health
  10. Dynamic combinatorial chemistry for nucleic acids

    SBC: FIREBIRD BIOMOLECULAR SCIENCES LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The proposed research will develop dynamic combinatorial chemistry as a new and innovative strategy to allow a DNA or RNA target in a biological sample to assemble its own template under conditions of dynamic equilibrium. This chemistry incorporates element that allows the template-created primer to primes the synthesis of a strand of DNA complementary to the t ...

    STTR Phase I 2007 Department of Health and Human ServicesNational Institutes of Health
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