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The Award database is continually updated throughout the year. As a result, data for FY21 is not expected to be complete until September, 2022.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Flexible Low Temperature CO2 Capture System, E-CACHYS

    SBC: ENVERGEX LLC            Topic: 1

    This project focuses on the design, integration and optimization of a flexible natural gas combined cycle plant with carbon capture, capable of operating in a highly variable renewable energy environment. Renewable energy sources such as wind and solar power offer unique solutions in our quest to reduce global carbon dioxide (CO2) emissions. However, the increasing penetration of these high variab ...

    STTR Phase II 2020 Department of EnergyARPA-E
  2. Xenon gas treatment to modulate microglia in neurodegenerative diseases

    SBC: General Biophysics LLC            Topic: NIA

    PHASE I APPLICATION(STTR Program PAS-19-317)“Xenon gas treatment to modulate microglia in neurodegenerative diseases” ABSTRACTAlzheimer’s disease (AD) is the most prevalent neurodegenerative disorder. Emerging evidence shows that homeostatic dysregulation of the brain immune system, especially that orchestrated by microglia, plays a significant role in the onset and progression of the diseas ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  3. A GIP Companion Drug for Enhancing Metabolic Benefits of Long-Acting GLP-1

    SBC: Velum Incorporated            Topic: NIA

    Project Summary There is a world-wide “twin epidemic” of obesity and Type 2 Diabetes (T2D), with an urgent need to find effective new drug treatments for inducing weight loss. Stable derivatives of the endogenous glucoregulatory hormone, glucagon-like peptide-1 (GLP1) are in clinical use for the treatment of T2D but are also of great interest as an emerging treatment of obesity. Another closel ...

    STTR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  4. Portable hand-held proprietary xenon inhaler for rapid reduction of opioid withdrawal symptoms

    SBC: NOBILIS THERAPEUTICS, INC.            Topic: NIDA

    Summary/Abstract People with opioid use disorder (OUD) experience aversive opioid withdrawal symptoms (OWS) including nausea, diarrhea, vomiting, and anxiety, which emerge when blood opioid levels wane. These symptoms perpetuate unprescribed opioid use and accompanying morbidity and mortality, costing society nearly $80 billion per year. Withdrawal symptoms also emerge upon initiation of OUD pharm ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  5. Development of therapeutics to treat fentanyl overdose using a validated animal model

    SBC: TORRALVA MEDICAL THERAPUETICS LLC            Topic: NIDA

    PROJECT SUMMARY: According to the Centers for Disease Control (CDC), synthetic opioids are currently the most common cause of overdose death in the U.S, while heroin and prescription opioid deaths have decreased significantly since 2017. Despite the widespread availability of naloxone, deaths from fentanyl and fentanyl analogues (F/FA) continue to rise in parallel with increasing reports of F/FA r ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  6. PARETO: Predictive Analytics to Realize Effective Training Operations

    SBC: Aptima, Inc.            Topic: N21BT024

    The key to enabling successful Naval aviation operations is safe, trained, and ready personnel. Current approaches to improving aviator performance, safety, and effectiveness have critical limitations. First, the Navy does not fully leverage the wealth of data collected and maintained in operational and training settings to make improvements. In part, this is because harnessing the data to gain kn ...

    STTR Phase I 2021 Department of DefenseNavy
  7. Integrated Computational Materials Engineering (ICME) Modeling Tool for Optimum Gas Flow in Metal Additive Manufacturing Processes

    SBC: TECHNICAL DATA ANALYSIS, INC.            Topic: N21BT022

    Users of additive manufacturing machines expect the highest quality when it comes to the mechanical properties of parts, the usability of the machines and associated processes, and overall machine design. The main contributor to the quality of the part is the involvement of process-related by-products originating from the melting process. To handle these by-products in additive manufacturing - in ...

    STTR Phase I 2021 Department of DefenseNavy
  8. Integrated Computational Materials Engineering (ICME) Modeling Tool for Optimum Gas Flow in Metal Additive Manufacturing Processes

    SBC: Global Engineering and Materials, Inc.            Topic: N21BT022

    Most existing simulation tools are deficient in modeling gas flow effects, which have been proven to significantly affect the build quality of metal additive manufacturing (AM). In Phase I, the research team will extend our current Integrated Computational Materials Engineering (ICME) modeling toolkit by including a multiscale and multiphysics simulation modules to predict the effect of gas flow o ...

    STTR Phase I 2021 Department of DefenseNavy
  9. Development of a commercially viable machine learning product to automatically detect rotator cuff muscle pathology

    SBC: Springbok, Inc.            Topic: NIAMS

    PROJECT SUMMARY Rotator cuff tears are highly problematic for large patient populations, and therefore remain a very challenging clinical problem. Roughly 20% to 50% of those 60 years of age have a known rotator cuff tear and the prevalence only increases with age. While surgical reconstruction of the rotator cuff seeks to improve shoulder function and stability, the degrees of successful surgical ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
  10. Triagonist Peptide Therapeutics for Neuroprotection

    SBC: Velum Incorporated            Topic: 300

    Project Summary Morbidity associated with neuronal degeneration and dysfunction poses an increasing public health burden. Among the wide range of etiologies that result in neuronal dysfunction, including chronic conditions such as Alzheimer’s and Parkinson’s disease and vascular dementias, one major cause that has been largely unnoticed but is increasingly recognized as a major concern is trau ...

    STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
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