Award Data

DESCRIPTION (provided by applicant): The general goal of this proposal is to assemble directed mutant gene sets quickly, cheaply, easily, and reliably. Mutant gene sets can share sub-assemblies, yielding savings of time, cost, and effort not possible if designed and assembled all as single genes. The approach is to build upon experience gained in Phase I, to extend and generalize methods of DNA de ...

DESCRIPTION (provided by applicant): The principal aim of this project is to develop a resource library of very high-resolution computer models and imaging data sets of human skulls. This skull database project, which builds upon and is an extension of the Tooth Atlas project, will be the first phase of a complete, whole body, osteology library. As the imaging and computer technology advances, th ...

DESCRIPTION (provided by applicant): DesignMedix has developed a novel class of compounds to address the pressing need for an orally available, inexpensive drug to counter the spread of chloroquine-resistant malaria. Preliminary data showed that this novel class of molecules, called reversed chloroquines (RCQs), acts against both chloroquine- resistant and chloroquine-sensitive malaria in vitro. ...

DESCRIPTION (provided by applicant): This Small Business Technology Transfer project seeks to develop a plant bioreporter for arsenic, a carcinogen that is widely dispersed in the environment and is one of the two most common contaminants at Superfund sites. Currently, extensive sampling and laboratory analysis of soil and water is often required to detect and monitor arsenic over large areas affe ...

DESCRIPTION (provided by applicant): The decline of motor and cognitive function in aging finds an extreme manifestation in the form of sarcopenia and senile dementia, most commonly of the Alzheimer's type. Both are associated with mitochondrial dysfunction. In sarcopenia there is accumulation of mitochondrial DNA (mtDNA) deletions and loss of oxidative capacity in the muscle. In the Alzheimer's b ...

DESCRIPTION (provided by applicant): During the first 3 years, children's long-term developmental trajectories are established, and the quality of parenting the child receives on a daily basis profoundly influences these trajectories. The transition to parenthood is a difficult one for many parents, however, and can lead to parental stress and social isolation and a lack of parenting competence an ...

DESCRIPTION (provided by applicant): Inadequate sensitivity and specificity of currently-used imaging methods for cancer screening of the breast motivates the development of new modalities capable of adding diagnostic information. EMAI (electromagnetic acoustic imaging) is a novel imaging method which exploits tissue electrical conductivity and acoustic properties for the purposes of cancer detect ...

DESCRIPTION (provided by applicant): This Phase II Small Business Technology Transfer study between Materia, Inc. and the University of Kansas intends to build upon successes of our STTR Phase I (R41 GM076765) by scaling up selected products, optimizing processes for their manufacture, and expanding the array of functionalized oligomers for commercialization. This proposal is a collaborative effor ...

DESCRIPTION (provided by applicant): Methods for the delivery of therapeutics, tracking dyes, genes and other substances into complex neural tissue, organotypic cultures and cell types are limited in their effectiveness. The biolistic process, based on acceleration of carrier particles to sufficient velocity, has recently been shown to be a relatively effectual delivery method for neuronal systems ...

DESCRIPTION (provided by applicant): This is a resubmission of a Phase II proposal, 2R42CA124191-02, which received a priority score of 181, to develop a tissue-based genetic test for BRCA2 hereditary ovarian cancer. Six percent of unselected US ovarian cancers are BRCA2 hereditary cancers with truncating mutations in the BRCA2 gene. It is important to know which ovarian cancer patients have BRCA ...