Award Data

Thegoal is to develop asoftwaretool that implementsa novelapproach applicableto fitgeneral pharmacologic, toxicology, or other biomedical data, that mayexhibita non-monotonic dose-responserelationship for which thecurrent parametricmodels fail. Thesoftwareexplores dose-responserelationships using both monotonicand non-monotonicmodels,and estimates theassociated doseresponsecurves,which can further ...

Nanoscale, material sensitive, imaging techniques are critical for progress in many disciplines as we learn to master science and technology at the smallest dimensions — on the nanometer to atomic-scale. However, progress in both science and technology is becoming increasingly limited by the constraints of current imaging techniques and metrologies. Fortunately, by combining coherent extreme UV ...

Traumatic injuries account for 30% of all life years lost in the US and is the leading cause of death for people under 46 years of age. Uncontrolled bleeding or hemorrhage constitute 30-40% of trauma related deaths and are considered to be a major cause o

Additive manufacturing (AM) has rapidly evolved into a valuable technique for making parts which, at times, cannot be fabricated through conventional machining methods, or for fabrication of small quantities of complex parts. One challenge in the area of AM is the lack of real-time feedback on the fabrication process and the quality of the part being made. This is especially critical given the rel ...

Terrorist use of radioactive nuclear materials via nuclear and/or radiological dispersion devices (dirty bombs) is a serious threat. Therefore, it is crucial to detect proliferation of nuclear material. Critical challenges include: (a) high sensitivity detection of signature emissions from radioactive isotopes, and (b) cost-effectiveness for deployment of sensor networks across large storage facil ...

he Storable Clean Ethane-ethylene Nitrous Engine (SCENE) is a proposed technology designed to provide upper stages and spacecraft with non-toxic, liquid, non-cryogenic, high-performance propulsion with an Isp on the order of 300 seconds. The propellant components are stored as liquids under their saturated vapor pressures. With the SCENE, nitrous oxide is used as an autogenously pressurized oxidiz ...

Uncertainty Reduction in High Speed Flight Vehicle Modeling | Approved for Public Release 18-MDA-9707 (3 Jul 18)

Based on the results of our Phase I work, one significant barrier to optimizing battery performance lies in understanding the relationship between bulk solids and particle flow properties and the flow into the die. Our hypothesis: an increase in quality batteries production can be achieved if powder preparation process can be optimized and the die filling process controlled. We feel that control o ...

Autoclaves are typically used to fabricate high-quality composite components with acceptable thermal properties and low void volume. They provide elevated temperature processing cycles and external pressure required for adequate compaction to achieve these desired properties. However, autoclaves represent large capital and energy investment while limiting the size of fabricated parts and productio ...

For this research program, Mainstream will collaborate with Colorado State University (CSU) to develop a nanostructured heater capable of curing aerospace grade composites out-of-autoclave (OOA). The use of autoclaves is the primary cost driver in composite manufacturing due to size limitations, long processing times, and inefficient energy usage. Therefore, the Navy is looking to develop a nanost ...