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The Award database is continually updated throughout the year. As a result, data for FY21 is not expected to be complete until September, 2022.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

  1. Personalized anesthetic brain monitoring:Developing novel systems, sensors, and algorithms for aging, dementia, and Alzheimers disease patients

    SBC: PASCALL Systems, Incorporated            Topic: R

    PROJECT SUMMARY In the United States, nearly 100,000 patients receive general anesthesia and sedation daily to safely undergo surgical and non-surgical procedures. A high proportion of these patients are older than 65 years of age. These older patients are at higher risk of post-operative delirium and cognitive dysfunction. Many of these older patients have dementia, including mild cognitive impai ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  2. CD73 for sepsis

    SBC: Purine Pharmaceuticals Inc.            Topic: NIAID

    SUMMARYSepsis is a medical condition caused by an overwhelming systemic inflammatory response to infection. Although the underlying infection can now be efficiently treated with antibiotics, there are no effective therapies to control the organ damage caused by the inflammatory response of the host. As a result, sepsis is the leading cause of mortality in intensive care units and is the tenth lead ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  3. Novel OCT Technology for Detection of Occult Sperm in the Testes inNon- Obstructed Azoospermia.

    SBC: Unasper, Inc.            Topic: NICHD

    Non-obstructive azoospermia (NOA), a lack of sperm in the ejaculate due to defective spermatogenesis, affects as many as 100,000 men in the US, and represents an unmet medical need because many of these men would like to father children, but cannot without surgical intervention. Current therapy for such men is suboptimal, because it relies upon microsurgical testicular sperm extraction (micro-TESE ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  4. High Density Cell Respirator (HDCR) for the production of vectors, viruses and vaccines

    SBC: XDemics Corporation            Topic: NCATS

    PROJECT SUMMARY/ABSTRACT This Phase I/II STTR Fast Track proposal responds to the call from the 2018/2019 NCATS SBIR/STTR Research Priorities to develop technologies so that “new treatments and cures for disease can be delivered to patients more quickly”. The production of life-altering gene editing vectors, cancer killing viruses, and life- saving vaccines currently depends on traditional cel ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. Clinical feasibility of a non-invasive, low-cost wearable for measuring air trapping in COPD

    SBC: Respira Labs, Inc.            Topic: NHLBI

    ABSTRACTChronic Obstructive Pulmonary Disease (COPD) is the third leading cause of hospitalization in the US. Exacerbations - a worsening or “flare up” of symptoms - cause most COPD hospitalizations. Since most exacerbations can be treated with changes of inhalers and/or oral medications, at-home detection of lung function deterioration may facilitate earlier intervention and help delay or pre ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  6. The Assessment of Smart Phone Everyday Tasks (ASSET): A new IADL test for early AD

    SBC: ADK Group, LLC            Topic: NIA

    Project SummaryImpairment in instrumental activities of daily living (IADL) is a hallmark of Alzheimer’s disease (AD) dementia and a major source of patient and caregiver burden. Similarly to cognitive changes in AD, subtle difficulties in IADL may begin even before the stage of amnestic mild cognitive impairment (MCI). Recently, greater emphasis has been placed on preclinical AD, which consists ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  7. A novel device for cervical insufficiency in pregnant women

    SBC: Cx Therapeutics, Inc            Topic: NICHD

    Abstract In normal pregnancy, the cervix remains closed until term and then dilates under the influence of uterine contractions. In cases of cervical insufficiency (CI), the cervix dilates in the second trimester in the absence of uterine contractions, which leads to a preterm birth. Infants born prematurely are at risk of lifelong morbidities including chronic lung disease, feeding difficulties, ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Developing novel technologies to monitor nociception and opioid administration during surgery and general anesthesia in order to minimize post-operative opioid requirements

    SBC: PASCALL Systems, Incorporated            Topic: NIDA

    PROJECT SUMMARY In light of the opioid crises, minimizing postoperative pain and postoperative opioid requirements to reduce chronic opioid dependency among surgical patients have become major concerns for surgeons and anesthesiologists. Effective intraoperative nociception control can mitigate these concerns. Unfortunately, existing nociceptive monitoring tools use indicators that are inherently ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  9. Enabling Technology- Reducing Greenhouse Gas Emissions and Energy Demands in the Meat Production Industry via Scaling Advanced 3D Culture Bioreactors

    SBC: Cambridge Crops, Inc.            Topic: G

    Food production, and in particular animal-derived meat products, are a major source of green-house gases, compounded by the remarkable inefficiency in biomass conversion (grain to dense muscle tissue in meat), along with growing challenges with food safety, quality and nutrition. To address this growing problem, we propose to exploit the emerging field of cellular agriculture (tissue engineering o ...

    STTR Phase I 2020 Department of EnergyARPA-E
  10. Enabling Technology- Reducing Greenhouse Gas Emissions and Energy Demands in the Meat Production Industry via Scaling Advanced 3D Culture Bioreactors

    SBC: Cambridge Crops, Inc.            Topic: G

    Food production, and in particular animal-derived meat products, are a major source of green-house gases, compounded by the remarkable inefficiency in biomass conversion (grain to dense muscle tissue in meat), along with growing challenges with food safety, quality and nutrition. To address this growing problem, we propose to exploit the emerging field of cellular agriculture (tissue engineering o ...

    STTR Phase II 2020 Department of EnergyARPA-E
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