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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Increased Expression of an HIV CJ505.664 SOSIP Envelope in Plants by Modulation of ER Chaperones

    SBC: Plant Vax, Inc.            Topic: NIAID

    The recombinant HIV SOSIP EnvelopeEnvtrimer is the leading HIV vaccine candidate but current production levels are low in mammalian cell lineslikely due to current trimer designs which include numerous disulfide bondsproteolytic cleavage and extensive glycosylationknown to induce endoplasmic reticulumERstress and cellular toxicityThis proposal will utilize the Nicotiana benthamiana pN bpplant expr ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Development of Nanvas TM (Oil in Water Nanoemulsion Adjuvant) Formulated Allergens as Intranasal Immunotherapeutic Vaccines for Peanut Allergy

    SBC: BLUEWILLOW BIOLOGICS INC            Topic: NIAID

    Food allergy is an emerging health problem with increasing incidence and severityparticularly in childrenand continuing throughout adulthoodSincethe incidence of self reported peanut allergy has risen significantly representing a mounting financial burden to the healthcare systemWith no approved therapeutics availablevarious forms of immunotherapy have been evaluated but generally do not facilitat ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. TOPIC #384- PHASE I (FAST TRACK) SBIR CONTRACT- FINCARE: ENABLING PROVIDERS AND PATIENTS TO MAKE INFORMED CHOICES AND MINIMIZED FINANCIAL HARDSHIP

    SBC: CARE PROGRESS LLC            Topic: NCI

    This research project seeks to create innovative software that aids healthcare providers to calculate the out of pocket costs of patients receiving cancer treatmentThe goals of this SBIR project are to leverage the insights of stakeholderssubject matter experts and industry standards to create a software system that can be integrated into the workflow of providersIf we are successfulhealthcare pro ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. TOPIC 386: NOVEL ORALLY BIOAVAILABLE PDE-CATENIN INHIBITOR CONCENTRATES IN LUNG FOR CANCER CHEMOPREVENTION

    SBC: ADT Pharmaceuticals, LLC            Topic: NCI

    This application is based on ADT Pharmaceuticalsdiscoveries thatthe cGMP degrading phosphodiesterase isozymephosphodiesteraseAPDEis overexpressed during early stages of tumorigenesisgenetic knockdown of PDEresults in selective apoptosis of tumor cells by activating cGMP PKG signalingandsmall molecule inhibitors of PDEinduce apoptosis by PKG phosphorylation of oncogeniccateninthereby suppressing Tc ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. TOPIC 385: CARE4AHEAD: CREATING A SCALABLE TECHNOLOGY SOLUTION TO IMPROVE LONG-TERM CARE FOR CANCER SURVIVORS- MOONSHOT

    SBC: CARE PROGRESS LLC            Topic: NCI

    The goal of this SBIR project is to create a prototype of an innovative software system to help cancer survivors better manage their symptoms and stay connected with their clinicians over the course of their livesThis will include enabling survivors to report symptoms they may be experiencingcollect and transmit real time measurements from wearable sensors and receive notifications and reminders t ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. TOPIC 383: MULTI-CORE BIOPSY DEVICE WITH VOLUMETRIC FIELD OF TISSUE ACQUISITION (MOONSHOT)

    SBC: ROBIN MEDICAL INC            Topic: NCI

    The problemTumor recurrence or resistance to treatment often arises due to tumor heterogeneityThere is a need to develop smart biopsy devicesto collect biopsies from multiple tumor coresto identify locations of the biopsiesto maintain physical characteristics of tumor on the extracted samplesto be used under current image guided practicesWe propose to further develop a prototype of multi core biop ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. SBIR PHASE I TOPIC 392: TARGETED RADIONUCLIDE THERAPY OF METASTATIC LIVER CANCER: PATIENT SPECIFIC OPTIMIZATION

    SBC: RADIOPHARMACEUTICAL IMAGING AND DOSIMETRY, LLC            Topic: NCI

    Radioembolization using Ymicrospheres delivered into the hepatic artery under fluoroscopy guidance has slowed tumor progression in the liver for patients diagnosed with metastatic colorectal cancermCRCTreatment planning is based on a simple estimate of the average absorbed doseADdelivered to the treated volumetumor dose thus depends on tumor burden and tumor to background ratioresulting in under d ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. TOPIC 389- INTELLIGENT SOFTWARE FOR RADIATION THERAPY PLANNING

    SBC: RADIASOFT LLC            Topic: NCI

    Besides surgeryradiotherapy is the most effective treatment modality for localized prostate cancerThe success of radiotherapy stems from the exploit of a therapeutic window in tumor response and normal tissue tolerance which maximizes the chance of sterilizing the tumor while sparing the surrounding normal tissue from severe damageThis requires an accurate and individualized radiation dose distrib ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Development and evaluation of an all-in-one integrated webbased buprenorphine treatment program for opioid use disorder (Digital Interventions for Opioid Disorders- DIOD)

    SBC: WORKIT HEALTH INC            Topic: NIDA

    Workit Health will develop an automated system that helps clinicians organize and analyze patient dataPatients will express higher rates of treatment adherence in Medication Assisted Treatment in conjunction with psychosocial supportWorkit Health will conduct a randomized clinical trial that combines psychosocial support through CBT modules and peercounselor support and the DIOD program which adds ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Strong protections, tracking, diversion detection, and deactivation of opioid medications in the hospital and related caregiving settings.

    SBC: Curazel LLC            Topic: NIDA

    Under the Small Business Innovation Research ProgramSBIRPhase I programTopicthe Contractor will develop a comprehensive approach to allow hospitals gain control of their opioid medicationsThe Contractor approach is totrack opioids from the pharmacy to the patienttrack the amount given to the patientand for opioid waste to track it back to the pharmacybetter administer opioids to patients that offe ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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