Award Data

Electro-optical infrared and long wavelength infrared detectors and sensors are increasingly important for the Chemical/Biological Defense community. Solid-state optical cooler materials are in demand for replacing mechanical closed cycle coolers used in current LWIR standoff sensors to achieve cryogenic temperatures. Recent advances in optical cooling of rare-earth doped materials are pointing to ...

The proliferation of weapons of mass destruction (WMDs) presents a serious security threat to U.S. and allied personnel around the world. Military personnel and first responders must be prepared to operate under a wide range of chemical, biological, radiological, nuclear (CBRN) threats. Commercially available CBRN protective suits are bulky offering little dexterity to the wearer, therefore new st ...

Chemical, Biological, Radioactive and Nuclear (CBRN) protective ensembles are widely used by the US Military and civilian first responders as the first line of defense for personnel working in contaminated environments. Many innovative products have been developed for the chemical protective clothing market in response to demand from the market place for improved performance. However, the need for ...

Chemical warfare agents such as the lethal nerve agent soman are a major source of risk to military personnel. Currently, pyridostigmine bromide (PB) is the only FDA-approved pretreatment to counteract the effects of soman. The rationale behind PB administration is that it acts as a “temporary” inhibitor of AChE. This precludes nerve agents from irreversible inactivation of AChE, thereby mitig ...

In response to the defined need for minimizing the carry weight of combat teams while retaining capability, Luna Innovations is proposing the development of a stable formulation of atropine and scopolamine for use in an autoinjector to combat nerve agent intoxication. The combined formulation of atropine and scopolamine will allow for better treatment with more physiological coverage within the hu ...

The standard US military treatment for nerve agent exposure is application of up to three autoinjectors, each containing atropine sulfate and 2-pralidoxime, to counteract symptoms of nerve agent intoxication and restore acetylcholinesterase activity. This treatment increases survival rates after nerve agent exposure, however, seizures resulting from nerve agent poisoning are a common symptom that ...

CMC Pharmaceuticals, Inc. (Cleveland, OH) is proposing developing a stable, combination product of two small molecule drug candidates as a counter measure to chemical warfare nerve agents (NA). The combination product is expected to exploit complementary pharmacological profiles for optimal muscarinic receptor blockade and anticholinergic activity within the peripheral and central nervous system. ...

To address the Chemical and Biological Defense (CBD) need for a field-portable mass spectrometer for small molecule drugs in clinical samples, Physical Optics Corporation (POC) proposes to develop a new FiEldable DRug Mass Analysis (FERMA) system based on a combination of portable mass spectrometry technology with laser desorption/ionization for use with aqueous clinical samples. The FERMA system ...

We propose a novel two-dimensional mass spectrometry (2D-MS) technique based on ion trap arrays to identify illicit and designer drugs. This approach will give an unprecedented multiplex advantage for miniature mass spectrometry, allowing novice field technicians to rapidly identify drugs affecting the central nervous system based on both the m/z ratio and fragmentation pattern of an ion. Towards ...

This proposal will investigate the requirements for an automated system that can provide triage, treatment, and diagnostic support for skin infections and other non-domestic dermatological conditions military personnel are at risk of contracting. 3Derm Sy