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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

Displaying 1 - 10 of 5962 results
  1. Genome-scale De Novo DNA Synthesis on Electronic p-Chips with Sorting

    SBC: PHARMASEQ, INC            Topic: 172

    DESCRIPTION provided by applicant The purpose of the present project is to develop and validate a new method for synthesizing large number of DNA fragments oligodeoxynucleotides The method which is called andquot sequence directed DNA synthesisandquot involves the use of small electronic circuits andquot p Chipsandquot each of which transmits a unique ID number via RF when illuminated w ...

    SBIR Phase II 2015 Department of Health and Human Services
  2. An ODNP Probe to Study Hydration Dynamics in Membrane Protein

    SBC: BRIDGE 12 TECHNOLOGIES, INC.            Topic: 400

    DESCRIPTION provided by applicant The proposed research focuses on the development of a cost effect turn key probe for liquid state Overhauser Dynamic Nuclear Polarization ODNP spectroscopy to study the site specific translational dynamics of water molecules located at the interface of bio macromolecules such as membrane proteins It will allow researchers to readily perform ODNP experiments ...

    SBIR Phase I 2015 Department of Health and Human Services
  3. TDP-43 aggregation inhibitors for the treatment of ALS

    SBC: Aquinnah Pharmaceuticals Inc.            Topic: 105

    DESCRIPTION provided by applicant There is currently no therapy for Amyotrophic Lateral Sclerosis ALS which is a universally fatal neurodegenerative disease that afflicts over out of every individuals Protein aggregation has been implicated as a primary driving force in ALS and multiple other neurodegenerative illnesses TDP is the principle component of the protein aggregates i ...

    SBIR Phase I 2015 Department of Health and Human Services
  4. Image-Guided Transurethral HIFU for Genitourinary Therapy

    SBC: ACOUSTIC MEDSYSTEMS, INC.            Topic: 400

    DESCRIPTION provided by applicant Stress urinary incontinence SUI in women is an increase of pelvic floor compliance which results in decrease of urethral pressure typically through childbirth and presents as urine leakage during exertion SUI has significant impact on womenandapos s health including an association with increased levels of depression Curative options are limited to the in ...

    SBIR Phase II 2015 Department of Health and Human Services
  5. Low-Cost Sprayable Barrier for the Prevention of Surgical Adhesions

    SBC: Luna Innovations Incorporated            Topic: 300

    DESCRIPTION provided by applicant Adhesion formation after intra abdominal surgery poses a huge health risk cited as a leading cause of small bowel obstruction and female infertility Methods to prevent these adhesions are currently limited to barrier films which are difficult to place and are often restricted to use preventing adhesions to the surgical incision sie leaving the bulk of the ab ...

    SBIR Phase II 2015 Department of Health and Human Services
  6. Clinical Investigation of the Ceramide NanoLiposome for Advanced Solid Tumors

    SBC: KEYSTONE NANO, INC.            Topic: 102

    DESCRIPTION provided by applicant Keystone Nano in partnership with the University of Maryland Greenebaum Cancer Center UMD GCC proposes a multi site clinical evaluation of the Ceramide NanoLiposome CNL as a novel anti cancer therapeutic The overall objective of this project is to advance the CNL through a Phase I clinical trial The results of this trial will support subsequent trials ...

    SBIR Phase II 2015 Department of Health and Human Services
  7. Development of a low-cost, portable autorefractor for the measuring of refractive errors in low-resource settings

    SBC: PlenOptika, Inc.            Topic: NEI

    DESCRIPTION provided by applicant andquot Development of a low cost extended range autorefractorandquot This project proposal seeks to develop technologies that will lower the cost of and increase the accessibility of refractive eye care especially in low resoure settings We propose to advance our previously developed low cost handheld device capable of automati ...

    SBIR Phase I 2015 Department of Health and Human Services
  8. Development of biomarker of aging as predictor of AKI due to cardiac surgery

    SBC: HEALTHSPAN DIAGNOSTICS, LLC            Topic: N

    DESCRIPTION provided by applicant Acute kidney injury AKI is common expensive to treat and is associated with andgt mortality despite advances in supportive care Each year millions of patients undergo cardiovascular surgery medical imaging procedures or cytotoxic chemotherapy placing them at significant risk for developing AKI However while there is an immense clinical need to id ...

    SBIR Phase I 2015 Department of Health and Human Services
  9. Whole Eye Biometry System

    SBC: Physical Sciences Inc.            Topic: N

    DESCRIPTION provided by applicant Physical Sciences Inc PSI proposes to demonstrate a new dual conjugate dual band approach to whole eye optical biometry We will adapt a high speed SDOCT based scanning imaging system design recently developed for corneal scleral topography for application to the whole eye That system was based upon an ellipsoidal optical scanning imaging design that pro ...

    SBIR Phase II 2015 Department of Health and Human Services
  10. Rapid Magnetomotive Thrombolysis for Stroke

    SBC: Pulse Therapeutics, Inc.            Topic: 105

    DESCRIPTION provided by applicant Acute ischemic stroke AIS is the result of a blood clot in a cerebral artery It remains a leading killer and the leading cause of long term disabilit annually impacting over Americans Because brain tissue rapidly dies time to reperfusion is critical in both preventing death and improving neurological outcomes While current annual costs relat ...

    SBIR Phase II 2015 Department of Health and Human Services

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