Award Data

DESCRIPTION provided by applicant Acute ischemic stroke AIS is the result of a blood clot in a cerebral artery It remains a leading killer and the leading cause of long term disabilit annually impacting over Americans Because brain tissue rapidly dies time to reperfusion is critical in both preventing death and improving neurological outcomes While current annual costs relat ...

DESCRIPTION provided by applicant RNA interference RNAi is a small RNA guided gene silencing process within living cells The RNAi technique is widely used in both biological research and clinical applications because it has the ability to knockdown essentially any gene of interest However one major unresolved issue in RNAi studies is non specific gene silencing It is well known that in ...

DESCRIPTION provided by applicant Racial and ethnic minorities older adults and those from rural communities continue to be underrepresented in cancer and other clinical trials research despite annual spending on patient recruitment in excess of $ billion While many individual studies have demonstrated that targeted outreach and education to underrepresented patients and engagement of fro ...

DESCRIPTION provided by applicant Long term objectives Modified ribonucleic acids RNA are important regulators of numerous cellular processes and are increasingly being associated with human diseases For example non coding microRNAs play significant roles in neuronal development and can serve as biomarkers for psychiatric disorders Another such modified RNA is circular RNA circRNA a ...

DESCRIPTION provided by applicant Type diabetes is an immune mediated disease in which insulin producing beta cells are destroyed resulting in life long dependence on exogenous insulin The number of patients being diagnosed is increasing each year particularly in the very young Despite advances in glucose monitoring and insulin delivery there is a compelling need to identify therapies th ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project includes significant advances in societal goals on energy security, sustainability, low cost energy, and reduced greenhouse gas emissions. The convection battery is a systemic approach to improve the way normal (not flow) battery chemistries are used in large systems (>2 kWh). This technology ...

Most liquid high-level nuclear waste is currently being immobilized to a solid form as a borosilicate glass by vitrification. However, many nuclear wastes have complex and diverse chemical compositions that reduce their compatibility with borosilicate glass. The current baseline spent nuclear fuel reprocess generates secondary waste streams that generally include large amounts of MoO3 and noble me ...

DESCRIPTION provided by applicant Neuropathic pain such as diabetic neuropathic pain DNP can be difficult to treat with only of patients achieving meaningful andgt pain relief Current therapies e g duloxeline mainly address symptoms by focusing on blocking neurotransmission in the pain pathway with limited efficacy potentially severe side effects and narrow therapeutic in ...

DESCRIPTION provided by applicant Cells secrete hormones and neurotransmitter via exocytosis Understanding how exocytosis is regulated and how pharmaceuticals and toxins inhibit exocytosis is of broad medical significance because it aids in developing approaches to treat medical conditions where release of transmitter needs to be enhanced e g Parkinsonandapos s disease or inhibited e g ...

The broader impact/commercial potential of this Small Business Innovation Research Phase I project is the production of low cost glucose from biomass. The production of cost-competitive biofuels from biomass has been a significant industrial challenge due to the high cost of fractionation and conversion into sugars and biofuels. A renewable solvent has been shown to enable the efficient fractionat ...