Award Data

Timely management and closure of burn wounds are critical for proper emergency care and the assurance of positive outcomes for the warfighter. Current technologies rely on reagents that cannot respond effectively to the different classes of pathogens that

In this Phase I program, Fabrico Technology, Professor Leonid Bunegin of the University of Texas Health Science Center at San Antonio (UTHSC-SA), and Dr. Rocco Armonda, Director, Neuroendovascular Surgery and Neurotrauma, MedStar-Georgetown University Hos

Bioassays employed to evaluate the diverse range of biomarkers associated with organ injury are time-consuming, costly and require multiple instruments/testing formats to reach a diagnosis (i.e. fluorescence-based capture, ELISAs, PCR, etc.). Individually, these platforms are incapable of predicting the onset of irreversible organ tissue injury (e.g. kidney, liver, heart and lung). If a single mul ...

The objective of this project is to develop, produce, and commercialize a liquid-tight, field-applicable, ocular patch for wound stabilization and treatment of the eye following a war-related injury to the ocular surface. The patch consists of a curved flexible silicone membrane (similar in size and shape to a contact lens) which has had (1) a novel bio-adhesive

Currently, no commercial products exist for the repair of large injuries to muscle, particularly volumetric muscle loss (VML). In Phase I of this project, data demonstrated that keratin biomaterials can provide temporal release of growth factors while maintaining cell viability in vitro and in vivo. In Phase II, the biomaterial formulation was optimized for spatio-temporal delivery of cells and gr ...

Our warfighters are at great risk of large area burn wounds from incendiary munitions and improvised devices. Limitations of currently utilized field dressings greatly increase incidences of wound infection, further deterioration, shock and fatalities during CASEVAC to higher echelon levels of military medical care. During Phase I, Lynntech demonstrated strong proof-of-concept in vitro for a nov ...

Burn injuries, particularly those to the face, present a number of functional and psychological challenges that arise from scarring and related contracture. A major goal of trauma and burn surgeons is to prevent scarring and improve grafting technologies given the complexity of facial topography. This project seeks to optimize and finalize a prototype of a 3D printed keratin facemask capable of ...

Platelets play a central role in hemostasis and are responsible for many inherited and acquired bleeding disorders and thrombic events in human beings. A significant portion of post-trauma deaths are related to coagulopathy or hemorrhage events for both injured soldiers and civilian patients. Several platelet function analyzers have been designed and developed; however due to form-factor and/or ...

More than 1,500 Americans have lost a limb due to traumatic injury in combat in recent years.Upper limb loss can be treated with myoelectric prostheses, but such devices require intensive training to effectively operate. The need to concentrate and continuously react during training often takes amputees many months, with the result that many patients abandon use of the prosthesis. In the Phase I e ...

Phase I research culminated in the delivery of a prototype single-arm humeral head HHIO PTT which was well received by users. The prototype trainer development focused on providing an accurate simulation of the humeral head IO procedure, and was shown through usability testing to have been successful. Follow-on research is now called for to develop this proven technology into a commercially viable ...