Award Data

Intermediate and posterior uveitis cause 10% of blindness in the U.S. The mainstay of therapy is to eradicate the infectious cause and to quell the inflammation with corticosteroids or immunosuppressants. Delivery of anti-inflammatory drugs to the posteri

DESCRIPTION (provided by applicant): A novel and promising approach for achieving bony repair especially for large bone defects is to transplant human bone marrow stromal cells or mesenchymal stem cells (hMSCs). Culture expanded hMSCs, transplanted into i

DESCRIPTION (provided by applicant): Spinal disc herniation and the resulting symptoms of intractable pain, weakness, sensory loss, incontinence and progressive arthritis are among the most common debilitating conditions back problems. When conservative t

OUR EXPERIENCE AND EXPERTISE IN THE DEVELOPMENT OF EDUCATIONAL SOFTWARE WILL BE COMBINED WITH THAT OF EDUCATORS, PHYSICIANS, AND OTHER HEALTH SPECIALISTS TO DEVELOP MICROCOMPUTER EDUCATIONAL SOFTWARE UNDER THE TITLE MY GOOD HEALTH. MY GOOD HEALTH IS PLANNED AS A SERIES OF GAMES INTENDED TO STIMULATE SCHOOL CHILDREN IN THE PURSUIT OF A BETTER UNDERSTANDING OF HUMAN HEALTH, AND OF WHAT ACTION THEY C ...

DESCRIPTION (provided by applicant): The objective of this project is to develop and test display technology that will aid anesthesiologists in diagnosing and treating unexpected events. Unexpected events occur during 30% of all anesthesia cases. Thirt

THE LONG-TERM OBJECTIVE OF THE PROPOSED WORK IS TO PROVIDE PHYSICIANS AND OTHERS IN THE FIELD OF PREVENTIVE HEALTH CARE DELIVERY WITH AN INEXPENSIVE AND RELIABLE BIOCHEMICAL TEST TO MEASURE PATIENTS' EXPOSURE TO TOBACCO SMOKE. AT PRESENT, A RELIABLE TEST OF THIS TYPE IS NOT AVAILABLE ON A COMMERCIAL BASIS. COTININE, A METABOLITE OF NICOTINE, HAS BEEN SELECTED AS THE PRODUCT TO MEASURE BECAUSE OF I ...

URINARY TRACT INFECTIONS ASSOCIATED WITH URINARY DRAINAGE CATHETERS ARE A SIGNIFICANT CLINICAL PROBLEM RESULTING IN A PROLONGED HOSPITAL STAY AND AN INCREASED MORTALITY RISK. THIS PROPOSAL ADDRESSES A FEASIBILITY STUDY TO DETERMINE IF SURFACE MODIFICATION OF THE CATHETER WILL INHIBIT BACTERIAL MIGRATION. THE PROPOSED RESEARCH WILL TEST THE HYPOTHESIS THAT BACTERIAL FIVE DIFFERENT SURFACE TREATMENT ...

A TREATMENT OF HYDROPHILIC POLY(HYDROXYETHYL METHACRYLATE) CONTACT LENSES TO MINIMIZE IRREVERSIBLE PROTEIN ADSORPTION WILL BE TESTED. PROTEIN ADSORPTION ON LENSES NOT ONLY LEADS TO CLOUDING AND OPACITIES, BUT ALSO INDUCES WHAT APPEARS TO BE AN IMMUNE RESPONSE IN THE WEARER. THIS RESPONSE IS OBSERVED IN THE EARLY STAGES TO INCLUDE INCREASED MUCUS PRODUCTION, MILD ITCHING, DECREASED LENS TOLERANCE A ...

SINCE ANTIGENS RELEASED FROM TUMOR CELLS CAN THWART THE HOST'S IMMUNE REACTIVITY AGAINST IMMUNOGENIC TUMORS IN FAVOR OF TUMOR GROWTH, THE PRESENT WORK PROPOSES TO DEVELOP AN EXTRACORPOREAL SYSTEM TO REMOVE THE TUMOR ANTIGEN AS WELL AS THE BOUND ANTIGEN (ANTIGEN-ANTIBODY COMPLEX) FROM THE PATIENT'S PLASMA AND RETURN HIS/HER OWN PURIFIED PLASMA TO THE PATIENT. THE FIRST PHASE OF THE PROPOSED WORK IN ...

A NEED EXISTS FOR CHEAP, SIMPLE, SENSITIVE, AND RAPID NONISOTOPIC IMMUNOASSAYS FOR THE DETECTION OF PATHOGENIC VIRUSES, BACTERIA, AND CELLS. DEVELOPMENT OF AN INTERFACIAL LIGHT-SCATTERING IMMUNOASSAY (ISI) IS PROPOSED. SURFACE IMMOBILIZED ANTIBODIES PROVIDE TARGET ORGANISM SPECIFICITY WHILE TOTAL INTERNAL REFLECTION-GENERATED INTERFACIAL LIGHT SCATTERING PROVIDES INTENSE, TARGET-SPECIFIC SIGNAL. S ...