Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. MULTIPLY-TUNED MRS, LOCAL GRADIENT HEAD COIL

    SBC: Medical Advances, Inc.            Topic: N/A

    THE OBJECTIVE IS TO DEVELOP A VOLUME COIL FOR MULTI-FREQUENCY MR SPECTROSCOPY OF THE HUMAN BRAIN. THIS DEVELOPMENT IS EXPECTED TO SUBSTANTIALLY AID CLINICAL SPECTROSCOPIC RESEARCH IN PROVIDING A NON-INVASIVE METHOD OF MONITORING BIOCHEMISTRY AND PHYSIOLOGY IN A LESION. SIGNIFICANT IMPROVEMENTS ARE EXPECTED IN SENSITIVITY, UNIFORMITY, AND APPLICATION FEATURES OVER EXISTING COMMERCIAL PRODUCTS. THES ...

    SBIR Phase I 1992 Department of Health and Human Services
  2. PROCESS FOR CLONING DIFFERENTIALLY EXPRESSED GENES

    SBC: Novagen, Inc.            Topic: N/A

    THE RESEARCH WOULD INVESTIGATE THE FEASIBILITY OF A METHOD FOR DIRECT ISOLATION AND CLONING OF GENES ASSOCIATED WITH STATES OF DISEASE, CELL DIFFERENTIATION, OR METABOLIC INDUCTION. PHASE I STUDIES WILL FOCUS ON STEPS IN THE PROCESS THAT CURRENTLY LIMIT THE WIDESPREAD USE OF SUBTRACTIVE NUCLEIC ACID HYBRIDIZATION AS A MEANS OF ISOLATING THE TARGET GENES. IN PHASE II THIS TECHNOLOGY WILL BE INTEGRA ...

    SBIR Phase I 1992 Department of Health and Human Services
  3. MODIFIED SITE-SPECIFIC ENDONUCLEASE FOR GENOME RESEARCH

    SBC: PROMEGA CORP.            Topic: N/A

    WITH THE RAPID GROWTH OF HUMAN GENOME RESEARCH, THERE IS A GROWING NEED FOR ADVANCED MAPPING AND SEQUENCING METHODS. IN CURRENT METHODOLOGY, THERE IS NO SINGLE STEP PROCESS FOR GENERATING SPECIFIC DNA FRAGMENTS IN THE MEGABASE SIZE RANGE. PROMEGA WILL UNDERTAKE RANDOM MUTAGENESIS COUPLED WITH A POWERFUL, NOVEL GENETIC SELECTION TO ISOLATE FORMS OF AN INTRON-ENCODED SITE-SPECIFIC ENDONUCLEASE--I-PP ...

    SBIR Phase I 1992 Department of Health and Human Services
  4. INHIBITING TUMOR GROWTH BY RNASIN RIBONUCLEASE INHIBITOR

    SBC: PROMEGA CORP.            Topic: N/A

    AN INCREASING NUMBER OF RECENT TUMOR GROWTH STUDIES HAVE FOCUSED ON INHIBITION OF ANGIOGENESIS AS A MEANS OF PREVENTING TUMOR METASTASIS. AS A RESULT, SEVERAL ANTI-ANGIOGENIC AGENTS HAVE BEEN DESCRIBED, INCLUDING PLACENTAL RIBONUCLEASE INHIBITOR. PRELIMINARY RESEARCH COMPLETED BY PROMEGA CORPORATION IN COLLABORATION WITH THE UNIVERSITY OF WISCONSIN HAS INDICATED THAT AN ENDOTOXIN-FREE FORM OF RECO ...

    SBIR Phase I 1992 Department of Health and Human Services
  5. ELECTRO-MECHANICAL (EM) ACTUATOR DRIVER

    SBC: Advanced Motion Controls Inc.            Topic: N/A

    THE PROJECT WILL DEVELOP A NOVEL MINIATURE PULSE WIDTH MODULATED POWER DRIVER FOR ACTUATORS, I.E. DC MOTOR. THE POWER DRIVER WILL DELIVER 50 AT 50VDO IN A DOUBLE INON PACKAGE. THIS COMPACT DESIGN CAN ONLY BE ACHIEVED THROUGH THE INNOVATIVE COMBINATION OF MODER POWER SEMICONDUCTOR TECHNOLOGIES, PROPRIETORY CIRCUIT DESIGN, AND STATE-OF-THE-ART PACKAGING TECHNOLOGY WHICH UTILIZES NEW HEAT CONDUCTIVE ...

    SBIR Phase II 1992 Department of DefenseArmy
  6. OPTIMIZED PRODUCTION OF BACTERIAL AGENT-DEGRADING ENZYMES

    SBC: Bio-technical Resources, L.p.            Topic: N/A

    N/A

    SBIR Phase I 1992 Department of DefenseArmy
  7. PRODUCTION AND CHARACTERIZATION OF AN AVIAN RICIN ANTITOXIN

    SBC: OPHIDIAN PHARMACEUTICALS, INC.            Topic: N/A

    OPHIDIAN PHARMACEUTICALS PROPOSES TO TEST THE FEASIBILITY OF ADAPTING ITS TECHNOLOGY FOR PRODUCING AND PURIFYING THERAPEUTIC ANTIBODIES FROM THE EGG YOLKS OF HYPERIMMUNIZED LAYING HENS TO THE DEVELOPMENT OF RICIN ANTITOXIN. THIS TECHNOLOGY IS WELL SUITED TO THE RAPID DEVELOPMENT OF TOXIN-NEUTRALIZING THERAPEUTICS AGAINST HIGHLY-VARIABLE TOXINS OR A WIDE VARIETY OF TOXIC THREATS. COMMERCIALLY AVAIL ...

    SBIR Phase II 1992 Department of DefenseArmy
  8. HIGH TEMPERATURE, ABRADABLE COATINGS FOR TURBINE ENGINE COMPRESSORS

    SBC: THERMAL SPRAY TECHNOLOGIES, INC.            Topic: N/A

    THE COMPRESSION SYSTEMS OF CURRENT AND FUTURE GAS TURBINE ENGINES REQUIRE EXTREMELY TIGHT CLEARANCES IN THE HIGH PRESSURE COMPRESSOR IN ORDER TO OBTAIN AND MAINTAIN HIGH PERFORMANCE AND EFFICIENCY. MANY OF THE CURRENT COMPRESSORS USE THERMAL SPRAY COATINGS DEPOSITED ONTO THE COMPRESSOR SHROUDS WHICH ARE DESIGNED TO BE EASILY ABRADED BY THE TURBINE BLADE TIPS, THUS ACHIEVING TIGHT CLEARANCES. UNFOR ...

    SBIR Phase I 1992 Department of DefenseArmy
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