Award Data

THE PROJECT WILL DEVELOP A NOVEL MINIATURE PULSE WIDTH MODULATED POWER DRIVER FOR ACTUATORS, I.E. DC MOTOR. THE POWER DRIVER WILL DELIVER 50 AT 50VDO IN A DOUBLE INON PACKAGE. THIS COMPACT DESIGN CAN ONLY BE ACHIEVED THROUGH THE INNOVATIVE COMBINATION OF MODER POWER SEMICONDUCTOR TECHNOLOGIES, PROPRIETORY CIRCUIT DESIGN, AND STATE-OF-THE-ART PACKAGING TECHNOLOGY WHICH UTILIZES NEW HEAT CONDUCTIVE ...

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ALCOHOL ABUSE INFLICTS TERRIBLE DAMAGE ON THE ADULT WORKING POPULATION OF THIS COUNTRY AND COSTS INDUSTRY APPROXIMATELY $71 BILLION EACH YEAR, YET THERE ARE VIRTUALLY NO ADVANCED ALCOHOL ABUSE PREVENTION PROGRAMS IN INDUSTRY. ISA ASSOCIATES WILL DEVELOP AN ALCOHOL ABUSE PREVENTION PROGRAM FOR INDUSTRY, BASED ON A SOCIAL LEARNING MODEL AND CAST IN AHEALTH PROMOTION FRAMEWORK. THE PROGRAM WILL BE SU ...

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THE OBJECTIVE IS TO DEVELOP A VOLUME COIL FOR MULTI-FREQUENCY MR SPECTROSCOPY OF THE HUMAN BRAIN. THIS DEVELOPMENT IS EXPECTED TO SUBSTANTIALLY AID CLINICAL SPECTROSCOPIC RESEARCH IN PROVIDING A NON-INVASIVE METHOD OF MONITORING BIOCHEMISTRY AND PHYSIOLOGY IN A LESION. SIGNIFICANT IMPROVEMENTS ARE EXPECTED IN SENSITIVITY, UNIFORMITY, AND APPLICATION FEATURES OVER EXISTING COMMERCIAL PRODUCTS. THES ...

THE RESEARCH WOULD INVESTIGATE THE FEASIBILITY OF A METHOD FOR DIRECT ISOLATION AND CLONING OF GENES ASSOCIATED WITH STATES OF DISEASE, CELL DIFFERENTIATION, OR METABOLIC INDUCTION. PHASE I STUDIES WILL FOCUS ON STEPS IN THE PROCESS THAT CURRENTLY LIMIT THE WIDESPREAD USE OF SUBTRACTIVE NUCLEIC ACID HYBRIDIZATION AS A MEANS OF ISOLATING THE TARGET GENES. IN PHASE II THIS TECHNOLOGY WILL BE INTEGRA ...

OPHIDIAN PHARMACEUTICALS PROPOSES TO TEST THE FEASIBILITY OF ADAPTING ITS TECHNOLOGY FOR PRODUCING AND PURIFYING THERAPEUTIC ANTIBODIES FROM THE EGG YOLKS OF HYPERIMMUNIZED LAYING HENS TO THE DEVELOPMENT OF RICIN ANTITOXIN. THIS TECHNOLOGY IS WELL SUITED TO THE RAPID DEVELOPMENT OF TOXIN-NEUTRALIZING THERAPEUTICS AGAINST HIGHLY-VARIABLE TOXINS OR A WIDE VARIETY OF TOXIC THREATS. COMMERCIALLY AVAIL ...

RECENT BOMBESIN AND GASTRIN RELEASING PEPTIDE RECEPTOR ANTAGONISTS HAVE BEEN DEMONSTRATED TO B E QUITE POTENT IN INHIBITING THE EFFECTS OF BOMBESIN IN PANCREATIC ACINAR CELLS, BRAIN MEMBRANES, SWISS 3T3 FIBROBLASTS, AND HUMAN SMALL CELL LUNG CARCINOMA (SCLC). HOWEVER, THESE ANTAGONISTS DO NOT DISPLAY COMPARABLE HIGH POTENCY IN INHIBITING THE PROLIFERATION OF HUMAN SMALL CELL LUNG CARCINOMA. CERTAI ...

WITH THE RAPID GROWTH OF HUMAN GENOME RESEARCH, THERE IS A GROWING NEED FOR ADVANCED MAPPING AND SEQUENCING METHODS. IN CURRENT METHODOLOGY, THERE IS NO SINGLE STEP PROCESS FOR GENERATING SPECIFIC DNA FRAGMENTS IN THE MEGABASE SIZE RANGE. PROMEGA WILL UNDERTAKE RANDOM MUTAGENESIS COUPLED WITH A POWERFUL, NOVEL GENETIC SELECTION TO ISOLATE FORMS OF AN INTRON-ENCODED SITE-SPECIFIC ENDONUCLEASE--I-PP ...