Award Data

Diabetes is widely recognized as one of the leading causes of death and disability. Medical complicdiabetes can cause blindness, heart disease, stroke, kidney failure, nerve damage, and amputations.and Complications Trial researched the effect of intensive treatment on insulin dependent diabetics.that intensive treatment significantly reduces the number of complications that diabetics suffer. Thro ...

Operation of cooling tower and boiler systems requires frequent monitoring of water chemistry parameters to obtain the necessary information for adjustments to the water treatment program. Failure to perform the necessary adjustments can result in reduced service life and poor energy efficiency resulting from corrosion, scale and fouling. A hybrid absorbance/emission spectrometer is proposed as th ...

A reflectiver near infrared (NIR spectrometer is proposed for the noninvasive measurement of surface and deep tissue pH. Previous experimental studies have demonstrated on a preliminary basis the ability to estimate liquide pH in complex biological matrices based on NIR spectra [Dre 90][Sch 93], and the proposed development program will design, contruct and test an experimental bench NIR pH measu ...

The long-term objective of CCT is to develop and commercialize new transesophageal (TE) pacing systAvailable systems pace only the atria, but one, the other, or both heart chambers must be paced to sneeds in medical emergencies and Advanced Life Support protocols. This application describes clinicaprototype probes for TE atrial and/or ventricular pacing, including one for simultaneous pacing and(E ...

There is presently a great deal of interest in developing efficient, nontoxic, cell-specific gene tSpecifically, there has been a focused interest in the development of nonviral vectors which have setheir viral counterparts in that they cannot reconvert, they can be designed to carry a variety of gcan be modified with target vectors without disruption of activity. Recent work in collaboration witM ...

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We will establish the feasibility of integrating state-of-the-art multimedia (interactive video andanimation) into existing award-winning software - BARN (Body Awareness Resource Network). BARN was dthe University of Wisconsin (1981-88) to provide health promotion information directly to adolescentcomputer. BARN has been published since 1986 through learning Multi-Systems, Inc. (the applicant comr ...

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ORBITEC proposes a Miniature in-Situ Smart Fatigue Monitor (MISSFM) that will accurately assess and monitor fatigue damage in eal time of almost any structural component. Phase I will design and demonstrate technology to achieve a solid state device to measure and display component strain and calculate fatigue life (rainflow cycle couting and Miner's cumulative damage algorithms). A technical appr ...

With the increased understanding of the role of specific cytochrome P450 isoforms in drug metabolisgrowing need for improved in vitro methodology using purified P450s. The major drawbacks to currentinterference from contaminating enzymes present in heterogenous assay systemss and difficulties in rpurified P450s with there associated electron transfer proteins. We will extend technology developedEs ...