Award Data

Drug metabolism problems such as production of toxic metabolites and unfavorable pharmacokinetics cause almost half of all drug candidate failures during clinical trials. Although glucuronidation is one of the most important routes of drug metabolism, the broad and overlapping substrate specificity of the hepatic UDP-glucuronosyltransferases (UGTs) that catalyze glucuronidation remains poorly unde ...

Drug metabolism problems such as production of toxic metabolites and unfavorable pharmacokinetics cause almost half of all drug candidate failures during clinical trials. Although glucuronidation is one of the most important routes of drug metabolism, the broad and overlapping substrate specificity of the hepatic UDP-glucuronosyltransferases (UGTs) that catalyze glucuronidation remains poorly unde ...

Fine Needle Aspiration Biopsies (FNAB) are widely performed due to their minimally invasive nature, low cost, and rapid turn around time for the diagnosis of various mass lesions such as cancer and infection. With increasingly, their use is expected to increase further mainly due to the escalating incidence of cancer. In the future, with the prevalence of in s- situ molecular techniques., FNAB wil ...

Assisted Living Facilities (ALF) are the fastest growing means of providing assistance to the elderly with Alzheimer?s I Dementia (AD), but generally care is provided by untrained, nonprofessional staff. Therefore, the overall, long term goal of our program is to improve the quality of AD care for persons residing in assisted living facilities. In Phase I, the objective of the project was to devel ...

Assisted Living Facilities (ALF) are the fastest growing means of providing assistance to the elderly with Alzheimer?s I Dementia (AD), but generally care is provided by untrained, nonprofessional staff. Therefore, the overall, long term goal of our program is to improve the quality of AD care for persons residing in assisted living facilities. In Phase I, the objective of the project was to devel ...

DESCRIPTION (provided by applicant): The phenomenal growth of the Internet and telecommunications technologies offers the next major step in health care: efficient communication between patients and their health care providers. While there is a wealth of information from a variety of sources on health care and medical conditions, the tools to help patients put together their own experience in a fr ...

DESCRIPTION (provided by applicant): The DNA alphabet is not limited to the four standard nucleotides. Rather, twelve nucleobases forming six base pairs joined by mutually exclusive hydrogen bonding patterns are possible within the geometry of the Watson-Crick base pair. These form An Expanded Genetic Information System (Aegis), a new, "rule based" molecular recognition system that carries protein ...

DESCRIPTION (provided by applicant): The DNA alphabet is not limited to the four standard nucleotides. Rather, twelve nucleobases forming six base pairs joined by mutually exclusive hydrogen bonding patterns are possible within the geometry of the Watson-Crick base pair. These form An Expanded Genetic Information System (Aegis), a new, "rule based" molecular recognition system that carries protein ...

DESCRIPTION (provided by applicant): Cystic fibrosis is the most common autosomal recessive genetic disease in the United States. With the recent recommendation for multi-mutation CF screening by the ACMG/ACOG, more labs will be implementing multiplexed genotyping assays. Presently, DNA diagnostic tests for CF are expensive, complicated to run and limited to certain ethnic backgrounds. Using a po ...

DESCRIPTION (provided by applicant): The goal of this project, over Phase I and Phase II, is to develop and validate a new diagnostic platform for biowarfare detection that provides ultrafast design and implementation. Today, both the scientific and security communities believe that advances in biotechnology have increased the concern for misuse in biological weapon programs. As reports of anthrax ...