Award Data

Project Summary/AbstractNeurological and psychiatric disorders, including drug abuse and addiction, exert a devastating personal and economic toll on patients, families, caregivers, and society. This is in part due to our failure in developing effective medications, which in turn is due to the use of drug discovery platforms that are often not relevant to target diseases. The recent development of ...

Currently available anti-thymocyte globulin (ATG) products are polyclonal animal antibodies (ATGAM – equine polyclonal ATG, Thymoglobulin – rabbit polyclonal ATG) and have found broad use as immune tolerizing agents, particularly for induction therapy in a majority of tissue transplants, for acute transplant rejection, and as treatment for graft vs. host disease following bone marrow transplan ...

Nucleic acid testing offers the potential to improve tuberculosis diagnosis world wideHigh purity DNA is essential to the success of virtually any downstream nucleic acid detection methodWe propose to develop a sample preparation system to extract and purify Mycobacterium tuberculosis DNA from raw sputumThe project goalas described in the solicitationPHSTopicis to develop an inexpensive and easy t ...

Planned or unplanned traffic events, such as work zones, collision accidents, sporting games and stormy/snowy weather, arise along our roadway systems and affect normal traffic operations. These anomaly events cause various magnitude of traffic congestion and safety impact to road users. Thus, local or regional Traffic Management Centers (TMCs) have spent tremendous amount of resources responding ...

Project Summary Our goal is to develop a novel, immunologically enhanced L. lactis probiotic-based therapeutic for the treatment of Sjögren’s Syndrome (SjS). SjS is a progressive, chronic autoimmune disease characterized by inflammatory cell infiltration of the salivary and lacrimal glands, resulting in acinar epithelial cell atrophy, cell death, and loss of exocrine function1-6. At least half ...

Project Summary/Abstract Individuals suffering from Serious and Persistent Mental Illnesses (SPMI) are at risk for adverse psychiatric, somatic health, and social outcomes with higher rates of heart disease, high blood pressure, obesity, and diabetes. Essential to controlling chronic psychiatric and health disorders is improved care coordination and adherence to prescriptions that address the symp ...

PROJECT SUMMARY/ABSTRACT Severe kidney disease accounts for 7% of all Medicare and Medicaid costs. The most cost-effective way to perform dialysis uses an arteriovenous fistula to connect to dialysis machines, but fistula use is limited by the malfunctions immediately following creation (maturation failure), which can render up to 70% of all created fistulas unusable. Ultrasound monitoring of the ...

PROJECT SUMMARY The overall goal of the proposed research and technology transfer effort is to develop a low-cost, point-of-care, mobile device-based technology for automated identification of Stillandapos;s murmur, the most common innocent (benign and harmless) heart murmur of childhood. This novel technology could reduce the current rate of over half a million children unnecessarily referred to ...

Project Abstract/Summary The goal of the proposed studies is to continue and expand GlycoT’s research in a Phase I SBIR study to establish a robust and scalable process for production of hypersialylated glycoforms of intravenous immunoglobulin (IVIG) with markedly enhanced anti-inflammatory activity. We will achieve this goal by exploiting an innovative chemoenzymatic glycosylation remodeling te ...

AbstractSubstance use disorders (SUDs) continue to be one of the most serious public health problems in the US.1 Studies have consistently documented a substantially higher prevalence of SUDs among adults under criminal justice supervision in the community (i.e., probation or parole) as compared to the general population.2-4 There is growing recognition that addiction is a chronic health condition ...