Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Decentralized, Public, and Mobile-Based Sidewalk Inventory Tool

    SBC: KNOWLEDGE BASED SYSTEMS, INC.            Topic: 142FH1016

    Knowledge Based Systems, Inc. (KBSI) is pleased to propose the further design and development of “MySidewalk,” a mobile application facilitating the crowd-sourced collection of sidewalk inventory and condition data. MySidewalk utilizes advances in social networks, mobile data collection, and data mining to provide integrated sidewalk datasets. Phase I demonstrated the feasibility of the conce ...

    SBIR Phase II 2016 Department of Transportation
  2. Development of a small molecule activator of integrin cell adhesion to enhance therapeutic responses to checkpoint blockade in cancer

    SBC: 7 Hills Pharma LLC            Topic: 102

    DESCRIPTION provided by applicant Recent FDA approvals of ipilimumab nivolumab and pembrolizumab which target checkpoint receptors cytotoxic T lymphocyte associated antigen CTLA and programmed death PD have ushered in a new era of cancer immunotherapy in metastatic melanoma Despite unprecedented overall survival benefits with combination therapy the incidence of complete respo ...

    STTR Phase I 2016 Department of Health and Human Services
  3. Optimization of the Production and Isolation of the Novel Antifungal Occidiofungin

    SBC: Sano Chemicals, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Occidiofungin is a cyclic nonribosomally synthesized antifungal peptide with submicromolar fungicidal activity against a broad spectrum of fungi Occidiofungin is produced by the Gram negative bacterium Burkholderia contaminans From our structural characterization studies occidiofungin was determined to have a unique chemical composition Our studies have als ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a STAT2 knock-out hamster model for wild-type filovirus infections

    SBC: Auratus Bio LLC            Topic: 200

    DESCRIPTION provided by applicant Golden Syrian hamsters offer certain advantages over the use of other rodents in the study of a number of human diseases In the context of cancer research the histological and cytogenetic changes in the development of pancreatic cancers are similar in humans and hamsters but not in mice Hamsters are also the model species of choice for studying oncolytic ad ...

    STTR Phase I 2016 Department of Health and Human Services
  5. Digital Gene Expression Analysis by 3’ End Sequencing

    SBC: BIOO SCIENTIFIC CORPORATION            Topic: 172

    DESCRIPTION provided by applicant A key application of deep sequencing is gene expression analysis at the RNA level commonly known as RNA seq Reads from RNA seq cover all regions of an mRNA sequence However sequences derived from the andapos end region are sufficient to indicate gene expression levels All andapos end sequencing methods have revealed that most eukaryotic genes display a ...

    STTR Phase I 2016 Department of Health and Human Services
  6. Aptamers and BSI for Sub-Microliter Analysis of Pharmaceuticals in Neonatal Urine

    SBC: Base Pair Biotechnologies, Inc.            Topic: NICHD

    DESCRIPTION provided by applicant Neonatal and pediatric intensive care still involves performing painful needle punctures to obtain blood samples for routine clinical monitoring Pain management in the neonatal setting is often achieved by long term continuous intravenous infusion of morphine or related compounds It has become increasingly clear however that long term use of opioid compound ...

    STTR Phase I 2016 Department of Health and Human Services
  7. An eHealth solution for posttraumatic stress and pain screening integrated in pediatric injury care

    SBC: Radiant Creative Group, LLC            Topic: NICHD

    DESCRIPTION provided by applicant Each year million US children are injured affecting the child his her family and society which often bears the cost Among school age children age to injuries lead to million emergency department ED visits and hospital admissions annually resulting in $ billion in medical costs and $ billion more in work loss costs Approxima ...

    STTR Phase I 2016 Department of Health and Human Services
  8. Optimized lactoferrin for treatment of intracerebral hemorrhage

    SBC: PHARMAREVIEW CORPORATION            Topic: 101

    DESCRIPTION provided by applicant Intracerebral hemorrhage ICH is a major public health problem with the highest mortality rate of all stroke subtypes ICH is one of the leading causes of long term disability Since there are no available FDA approved therapies for ICH it is of vast importance to search for new approaches in treatment for this devastating medical condition Lactoferrin LT ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Oral Small Molecule STAT3 Inhibitor to Treat Cachexia in Chronic Kidney Disease

    SBC: StemMed, Ltd.            Topic: NIDDK

    DESCRIPTION provided by applicant Chronic kidney disease CKD is a major public health problem in the US with an estimated prevalence of million patients enter hemodialysis or peritoneal dialysis programs yearly A serious complication in of patients with CKD is cachexia or muscle wasting which decreases quality of life and increases morbidity and mortality Unfortunately ...

    STTR Phase I 2016 Department of Health and Human Services
  10. Rapid and Simple Device for Point-of-Care Molecular Detection of Arboviruses


    Expensive equipment highly trained personnel and the need for a clinical laboratory setting precludes routine nucleic acid testing NAT for infectious disease in most of the developing world and even in many resource limited parts of the United States leading to wide disparities in health care worldwide A fast sensitive low cost but a facile NAT method for robust detection of specific agent ...

    SBIR Phase I 2016 Department of Health and Human Services
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