Award Data

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THERMOPLASTIC ELASTOMER (TPE) BY INJECTION MODLING OFFERS AN ALTERNATE METHOD FOR FORMING CHEMICAL PROTECTIVE GLOVES A SOCMPARED TO THE CONVENTONAL DIP PROCESS USING BUYTL RUBBER SOLUTIONS. THE ADVENT OF VARIOUS TPES WITH OLEFINIC, STYRENIC, URETHANE, ENGINEERING RESINS AND ALLOYS AND BLENDS OFFER THE ADVANTAGE OF INJECTION MODLING PRODUCTS WHICH HAVE BEEN CONVENTIONALLY MADE BY ELASTOMER COMPOUND ...

THE PROJECT WILL DEVELOP A NOVEL MINIATURE PULSE WIDTH MODULATED POWER DRIVER FOR ACTUATORS, I.E. DC MOTOR. THE POWER DRIVER WILL DELIVER 50 AT 50VDO IN A DOUBLE INON PACKAGE. THIS COMPACT DESIGN CAN ONLY BE ACHIEVED THROUGH THE INNOVATIVE COMBINATION OF MODER POWER SEMICONDUCTOR TECHNOLOGIES, PROPRIETORY CIRCUIT DESIGN, AND STATE-OF-THE-ART PACKAGING TECHNOLOGY WHICH UTILIZES NEW HEAT CONDUCTIVE ...

THE PURPOSE OF THIS PROJECT IS TO IMPROVE THE RESOLUTION OF THE ATOMIC FORCE MICROSCOPE (AFM). EXISTING PROBES FOR AFMS ARE RELATIVELY BLUNT AT THE END (RADIUS OF CURVATURE CA. 50 NM), LIMITING INSTRUMENTAL RESOLUTION AND MAKING IMAGE INTERPRETATION DIFFICULT WHEN EXAMINING MACROMOLECULAR STRUCTURES (LENGTH SCALE 1-100 NM). WE WILL DEPOSIT MOLECULAR-SCALE CLUSTERS OF CONTROLLED SIZE (1-5 NM DIAMET ...

A VARIETY OF DIFFERENT APPROACHES ARE BEING TAKEN TO INCREASE THE SPED AND DECREASING THE SPEED AND DECREASE THE COST OF DNA SEQUENCING. ONE OF THE MAJOR CURRENT SEQUENCING TECHNOLOGIES IS THE DIDEOXYNUCLEOTIDE CHAIN-TERMINATING APPROACH ORIGINALLY DEVELOPED BY SANGER. WE WILL USE A VARIANT OF THIS APPROACH IN WHICH THE DIDEOXYNUCLEOTIDES WILL BE MODIFIED WITH AN IMINOBIOTIN GROUP. IMINOBIOTIN BIN ...

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AN ELECTROMECHANICALLY DRIVEN TOTALLY IMPLANTABLE TOTAL ARTIFICIAL HEART (TAH) WAS DEVELOPED RECENTLY AT BAYLOR COLLEGE OF MEDICINE. THIS EXPERIMENTAL PROTOTYPE WAS PROVED TO BE RELIABLE AND EFFECTIVE, YET SMALL ENOUGH TO IMPLANT INSIDE THE CHEST CAVITY OF AN AVERAGE HUMAN PATIENT. THIS TAH SYSTEM WAS ASSEMBLED BY SELECTING AND COMBINING THE BEST, SIMPLEST AND MOST RELIABLE FEATURES AVAILABLE FROM ...

CLINICAL USE OF MAGNETOENCEPHALOGRAPHIC (MEG) DATA WILL DEPEND UPON A VARIETY OF FACTORS, ONE OF WHICH IS THE RAPID DISPLAY OF ELECTRICAL SOURCES THAT PRODUCE SIGNALS WITHIN THE BRAIN. CURRENTLY, SINGLE DIPOLE APPROXIMATIONS OF THE SOURCE LOCATION ARE OVERLAID ON TWO-DIMENSIONAL MAGNETIC RESONANCE IMAGES (MRI) FOR DISPLAY OF THE UNDERLYING ANATOMY. THIS PROCEDURE IS SLOW AND IS A CRUDE APPROXIMATI ...

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IN THIS PHASE I EFFORT, WE WILL DEMONSTRATE THE ABILITY TO SCALE UP THE PRODUCTION OF A LEAD LIPOSOMAL FORMULATION CANDIDATE OF ACYLATED, LIPOPHILIC RHUTNF. WE WILL SUBJECT THE BACTERIAL RECOMBINANT PROTEIN TO ACYLATION WITH THE N-HYDROXYSUCCUNIMIDE ESTER OF CAPRYLIC ACID (C3) TO ACHIEVE LIMITED SUBSTITUTION (1.5 TO 2 RESIDUES PER TNF TRIMER). THE IDENTITY AND EXTENT OF SUBSTITUTION OF THE TARGET ...