Award Data

THIS GRANT WILL SEEK THE DEVELOPMENT OF AN AUTOMATED DNA SYNTHESIZER THAT IS ORDERS OF MAGNITUDE FASTER AND MORE COST EFFECTIVE THAN CURRENT COMMERCIAL DNA SYNTHESIZERS WHILE UTILIZING STANDARD DNA CHEMISTRY. THE GOAL IS TO AUTOMATE THE SOLVENT DELIVERY SYSTEM FOR THE WAFER DNA SYNTHESIS DEVICE AND TO EVENTUALLY AUTOMATE ALL ASPECTS OF THE DEVICE. ONCE COMPLETE AUTOMATION IS ACHIEVED, THE WAFER DN ...

THE CILIARY GANGLION INNERVATES SEVERAL IMPORTANT EYE TISSUES, INCLUDING THE CILIARY MUSCLE AND BODY, AND HAS BEEN SHOWN TO REGULATE AQUEOUS OUTFLOW AND ACCOMMODATION. THE EYE DISORDERS, GLAUCOMA AND PRESBYOPIA, MAY INVOLVE THE CILIARY GANGLION THROUGH ITS REGULATION OF AQUEOUS OUTFLOW AND VISUAL ACCOMMODATION. A SUBSTANCE THAT COULD DIRECTLY AND SPECIFICALLY STIMULATE THE CILIARY GANGLION MAY BE ...

THE LONG-TERM OBJECTIVE OF THIS RESEARCH IS TO DEVELOP TECHNOLOGY AND DEVICES FOR THE PRESERVATION AND DRYING OF PORCINE BIOPROSTHETIC OR HUMAN ALLOGRAFT HEART VALVES THAT ALLOW STORAGE IN A NONFROZEN STATE. ONCE REHYDRATED, THE POTENTIAL ADVANTAGES OF SUCH VALVES WOULD BE LONGER AND MORECONVENIENT STORAGE PREGRAFT, AND LONGER LIFE SPANS AND REDUCED THROMBOEMBOLYTIC RISK POSTGRAFT. PORCINE HEART V ...

SPEC HAS DEVELOPED AN INNOVATIVE LASER REMOTE PHASE-RESOLVED FLUORESCENCE SPECTROSCOPY (PRFS) TECHNOLOGY FOR THE DETECTION OF CLANDESTINE DRUG FACILITIES. THE TECHNOLOGY IS CAPABLE OF DETECTING ORGANIC SPECIES SUCH AS KEROSENE FILMS ON THE GROUND AND ON THE SURFACES OF RIVERS, STREAMS OR LAKES AND CAN DISTINGUISH THESE FILMS FROM OTHER PETROLEUM SLICKS. THE PRESENCE OF KEROSENE IN THESE WATERWAYS ...

THE LONG-TERM OBJECTIVE OF THIS RESEARCH IS TO DEVELOP A HIGH-PERFORMANCE INSTRUMENTATION SYSTEM FOR MULTIPLE-CHANNELNEURONAL WAVEFORM ACQUISITION AND DATA REDUCTION. THE SPECIFIC AIMS OF THIS PROJECT ARE TO: (1) INVESTIGATE THE ORGANIZATION AND CONTROL OF MULTIPLE DIGITAL SIGNAL PROCESSORS IN A MICROPROCESSOR SUBSYSTEM CAPABLE OF ACQUIRING UP TO 64 CHANNELS OF SIGNALS AND REDUCING THE NEURONAL SP ...

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THE LONG-TERM AIMS OF THIS PROJECT ARE TO CREATE AND COMMERCIALIZE A NEW FAMILY OF INTERFACES BETWEEN CHROMATOGRAPHY AND MASS SPECTROMETRY THAT PROVIDE MULTICHANNEL ELEMENT-AND ISOTOPE-SELECTIVE DETECTION CAPABILITIES. THE APPROACH IS BASED ON COUPLING A NEW THERMOSPRAY "UNIVERSAL INTERFACE" DEVELOPED AT VESTEC CORPORATION WITH A MICROWAVE-POWERED REACTION INTERFACE. THE THERMOSPRAY INTERFACE VAPO ...

OPHIDIAN PHARMACEUTICALS PROPOSES TO TEST THE FEASIBILITY OF ADAPTING ITS TECHNOLOGY FOR PRODUCING AND PURIFYING THERAPEUTIC ANTIBODIES FROM THE EGG YOLKS OF HYPERIMMUNIZED LAYING HENS TO THE DEVELOPMENT OF RICIN ANTITOXIN. THIS TECHNOLOGY IS WELL SUITED TO THE RAPID DEVELOPMENT OF TOXIN-NEUTRALIZING THERAPEUTICS AGAINST HIGHLY-VARIABLE TOXINS OR A WIDE VARIETY OF TOXIC THREATS. COMMERCIALLY AVAIL ...

THE PROJECT'S LONG-TERM OBJECTIVE IS TO DEVELOP AN ENHANCED,COMPUTERIZED HEALTH RISK APPRAISAL, THE ALL-CAUSE MORTALITY RISK PROFILE (ACMRP), INCORPORATING AN OBJECTIVE MEASURE OF PHYSICAL FITNESS, THE MAXIMAL GRADED TREADMILL STRESS TEST, INTO MORTALITY RISK FACTORS. MORE THAN 17,000 PATIENTS WITHOVER 140,000 PERSON-YEARS OF FOLLOWUP IN THE ONGOING AEROBICS CENTER LONGITUDINAL STUDY (ACLS) HAVE B ...

THE PROPOSED INVESTIGATION WILL PERFORM AN ELABORATE ERROR ANALYSIS AND WILL DEVELOP APPROPRIATE FORCE AND MEASUREMENT MODELS TO PRECISELY DETERMINE THE VANDENBERG-KWAJALEIN BALLISTIC MISSILE TRAJECTORY. AMONG THE ERROR SOURCES CONSIDERED WILL INCLUDE (1) STATION COORDINATE ERRORS FOR THE THREE TRACKING STATIONS LOCATED AT VANDENBERG, HAWAII AND KWAJALEIN; (2) GRAVITY ANOMALY MODEL ERRORS AT LAUNC ...