Award Data

Operational Technologies Corporation proposes to develop non-immunogenic DNA aptamers against unfractionated snake, scorpion, spider, and insect venoms as well as snake phospholipase A2 (PLA2) and melittin (major components of venoms) in Phase 1. OpTech will then test each of the final round aptamers for the ability to inhibit PLA2 and prevent cell lysis due to various venoms in a human fibroblast ...

There is an urgent Department of Defense (DoD) need for precision Positioning, Navigation, and Timing (PNT) for weapons systems and platforms operating in severely degraded or GPS-denied environments. Next-generation PNT systems using Alkali-atom and cold-atom physics have been demonstrated and are being actively developed by the Air Force and other DoD agencies. These emerging PNT technologies ...

AM Biotech proposes to develop X-Aptamer-functionalized NanoSponges (XANS) as a multi-valent snakebite antidote using synthetic, ambient-stable affinity molecules (X-Aptamers) coupled to nanoporous silica microparticles (nanosponges). XANS would be ambient-stable, universal, available in remote locations, and would not cause anaphylactic reactions. The antidote would be injected in the field at t ...

This proposal documents Phase II efforts of Tietronix Software Inc. as it relates to the combination of a multi-platform game with graphic novel elements in support of computer science education. Aegis is a software application that combines the playabili

This proposal aims to show the feasibility of designing a high-level data-parallel language extension to Python on graphics processing units (GPUs). This language extension cooperates with the CPython implementation and uses Python syntax for describing

C-CAT continues to successfully make complex large scale assemblies for hypersonic aerospace vehicles based on decades of Carbon-Carbon (C-C) fabrication experience. Current and future vehicle designs continually push the limits of C-C material capabiliti

This proposal is in response to announcement DTRT57-13-R-SBIR2 in the area 13.2-FH1, Development of Innovative Welding for High Performance Bridge Steel. It is proposed to use Homopolar Generator (HPG) Welding to join the high performance bridge steel in the 3” by 30” cross sections mentioned in the announcement in under 1 second. All of the energy required to perform the weld is stored in the ...

The social cognitive effects of the neuropeptide oxytocin have potential implications in matters related to national security. There are currently more than two hundred human trials studying the functions of oxytocin in clinical cohorts. However, problems associated with specificity and sensitivity of currently available oxytocin assay methods has been an impediment to advancement of research in t ...

The proposal described herein presents a novel Mode-Division-Multiplexing (MDM) to realize waveguide arrays with subwavelength waveguide pitches. Waveguide arrays are usually designed with waveguide pitches of about a few wavelengths in order to avoid cross-talk. Multiple-Input-Multiple-Output (MIMO) enabled MDM has been used to enhance data rate in multimode fibers beyond their dispersion limit. ...

Blood-based point-of-care (POC) diagnostics or remote diagnostics that require specialized equipment only available in centralized, commercial laboratories are currently limited by major logistical and technical barriers. Blood collection can be a traumatic, inconvenient, and inconsistent process that is based on decades-old technologies, such as the lancet-puncture, that are not amenable to new P ...