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A VARIETY OF DIFFERENT APPROACHES ARE BEING TAKEN TO INCREASE THE SPED AND DECREASING THE SPEED AND DECREASE THE COST OF DNA SEQUENCING. ONE OF THE MAJOR CURRENT SEQUENCING TECHNOLOGIES IS THE DIDEOXYNUCLEOTIDE CHAIN-TERMINATING APPROACH ORIGINALLY DEVELOPED BY SANGER. WE WILL USE A VARIANT OF THIS APPROACH IN WHICH THE DIDEOXYNUCLEOTIDES WILL BE MODIFIED WITH AN IMINOBIOTIN GROUP. IMINOBIOTIN BIN ...

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AN ELECTROMECHANICALLY DRIVEN TOTALLY IMPLANTABLE TOTAL ARTIFICIAL HEART (TAH) WAS DEVELOPED RECENTLY AT BAYLOR COLLEGE OF MEDICINE. THIS EXPERIMENTAL PROTOTYPE WAS PROVED TO BE RELIABLE AND EFFECTIVE, YET SMALL ENOUGH TO IMPLANT INSIDE THE CHEST CAVITY OF AN AVERAGE HUMAN PATIENT. THIS TAH SYSTEM WAS ASSEMBLED BY SELECTING AND COMBINING THE BEST, SIMPLEST AND MOST RELIABLE FEATURES AVAILABLE FROM ...

CLINICAL USE OF MAGNETOENCEPHALOGRAPHIC (MEG) DATA WILL DEPEND UPON A VARIETY OF FACTORS, ONE OF WHICH IS THE RAPID DISPLAY OF ELECTRICAL SOURCES THAT PRODUCE SIGNALS WITHIN THE BRAIN. CURRENTLY, SINGLE DIPOLE APPROXIMATIONS OF THE SOURCE LOCATION ARE OVERLAID ON TWO-DIMENSIONAL MAGNETIC RESONANCE IMAGES (MRI) FOR DISPLAY OF THE UNDERLYING ANATOMY. THIS PROCEDURE IS SLOW AND IS A CRUDE APPROXIMATI ...

THE UNDERSTANDING OF PROTEIN FUNCTION IS GREATLY ENHANCED BYTHE AVAILABILITY OF THREE-DIMENSIONAL STRUCTURAL INFORMATIONOBTAINED BY X-RAY CRYSTALLOGRAPHY. THIS IS TRUE FOR MEMBRANE AS WELL AS WATER-SOLUBLE PROTEINS, BUT THE LARGE, WELL-ORDERED THREE-DIMENSIONAL CRYSTALS REQUIRED FOR X-RAY ANALYSES HAVE BEEN DIFFICULT TO PRODUCE IN THE CASE OF MEMBRANE PROTEINS, AS THEY TEND MORE NATURALLY TO FORM ...

IT HAS BEEN ESTIMATED THAT APPROXIMATELY A HALF-MILLION PATIENTS ACQUIRE URINARY TRACT INFECTIONS IN ACUTE CARE HOSPITALS IN THIS COUNTRY EVERY YEAR. THE USE OF THE URINARY CATHETER HAS BEEN CITED AS THE MAJOR CAUSE FOR SUCH INFECTIONS, THE MOST NUMEROUS OF ALL NOSOCOMIAL INFECTIONS. THIS TREND OF STEADY OR EVEN INCREASING URINARY TRACT NOSOCOMIAL INFECTION IS EXPECTED TO CONTINUE BECAUSE OF AN AG ...

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IN THIS PHASE I EFFORT, WE WILL DEMONSTRATE THE ABILITY TO SCALE UP THE PRODUCTION OF A LEAD LIPOSOMAL FORMULATION CANDIDATE OF ACYLATED, LIPOPHILIC RHUTNF. WE WILL SUBJECT THE BACTERIAL RECOMBINANT PROTEIN TO ACYLATION WITH THE N-HYDROXYSUCCUNIMIDE ESTER OF CAPRYLIC ACID (C3) TO ACHIEVE LIMITED SUBSTITUTION (1.5 TO 2 RESIDUES PER TNF TRIMER). THE IDENTITY AND EXTENT OF SUBSTITUTION OF THE TARGET ...

MITOCHONDRIAL RESPIRATION INHIBITION IN TUMOR CELLS MAY OCCUR IN TWO MANNERS. ONE MECHANISM INVOLVES THE SYNTHESIS OF NITRIC OXIDE (NO) BY MACROPHAGES OR IFN-GAMMA MEDIATED INDUCTION OF NO SYNTHESIS IN TUMOR CELLS. WE HAVE RECENTLY ESTABLISHED A MURINE MACROPHAGE CELL LINE, EA13.5, THAT RELEASES A SOLUBLE MEDIATOR, NIMC, THAT CAUSES TUMOR CELL RESPIRATION INHIBITION INDEPENDENT OF NO PRODUCTION AN ...