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IT IS THE INTENT OF THE INVESTIGATORS TO DEVELOP A NEW DIAGNOSTIC TEST FOR USE DURING PREGNANCY TO IDENTIFY WOMEN AT ELEVATED RISK FOR PRETERM DELIVERY (PTD). AN IMMUNOASSAY USING A MONOCLONAL ANTIBODY DIRECTED AGAINST ONCOFETAL FIBRONECTION (FFN), A PREGNANCY-RELATED PROTEN OF PLACENTAL ORIGIN FOUND IN THE AMNIOTIC FULID, HAS BEEN STANDARDIEZED FOR THIS PURPOSE. PRELIMINARY STUDIES HAVE SHOWN THA ...

A VARIETY OF DIFFERENT APPROACHES ARE BEING TAKEN TO INCREASE THE SPED AND DECREASING THE SPEED AND DECREASE THE COST OF DNA SEQUENCING. ONE OF THE MAJOR CURRENT SEQUENCING TECHNOLOGIES IS THE DIDEOXYNUCLEOTIDE CHAIN-TERMINATING APPROACH ORIGINALLY DEVELOPED BY SANGER. WE WILL USE A VARIANT OF THIS APPROACH IN WHICH THE DIDEOXYNUCLEOTIDES WILL BE MODIFIED WITH AN IMINOBIOTIN GROUP. IMINOBIOTIN BIN ...

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AN ELECTROMECHANICALLY DRIVEN TOTALLY IMPLANTABLE TOTAL ARTIFICIAL HEART (TAH) WAS DEVELOPED RECENTLY AT BAYLOR COLLEGE OF MEDICINE. THIS EXPERIMENTAL PROTOTYPE WAS PROVED TO BE RELIABLE AND EFFECTIVE, YET SMALL ENOUGH TO IMPLANT INSIDE THE CHEST CAVITY OF AN AVERAGE HUMAN PATIENT. THIS TAH SYSTEM WAS ASSEMBLED BY SELECTING AND COMBINING THE BEST, SIMPLEST AND MOST RELIABLE FEATURES AVAILABLE FROM ...

CLINICAL USE OF MAGNETOENCEPHALOGRAPHIC (MEG) DATA WILL DEPEND UPON A VARIETY OF FACTORS, ONE OF WHICH IS THE RAPID DISPLAY OF ELECTRICAL SOURCES THAT PRODUCE SIGNALS WITHIN THE BRAIN. CURRENTLY, SINGLE DIPOLE APPROXIMATIONS OF THE SOURCE LOCATION ARE OVERLAID ON TWO-DIMENSIONAL MAGNETIC RESONANCE IMAGES (MRI) FOR DISPLAY OF THE UNDERLYING ANATOMY. THIS PROCEDURE IS SLOW AND IS A CRUDE APPROXIMATI ...

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THE ANALYSIS OF EXTREMELY SMALL SAMPLES OF BIOLOGICAL COMPOUNDS REQUIRES EVER INCREASING SENSITIVITY OF MASS SPECTROMETRY. THIS IS EXPECIALLY THE CASE WITH HIGH MASS SAMPLES AND MS/MS ANALYSIS. THE GREATEST LOSS OF SENSITIVITY IN FAB AND LSMINS OCCURS DURING THE SPUTTERING CONVERSION OF SAMPLE MOLECULES IN THE LIQUID MATRIX TO SAMPLE IONS IN THE VAPOR STATE. FOR EXAMPLE, THE CONVERSION EFFICIENCY ...

WE HAVE RECENTLY DEVELOPED IN NUDE MICE ORTHOPEDIC METASTASIZING ONPLANT MODELS FOR COLON, BLADDER, LUNG, HEAD AND NECK, PROSTATE, STOMACH, OVARIAN, PANCREAS AND BREAST CANCERS. WE WILL UTILIZE SEVERE COMBINED IMMUNODEFICIENT (SCID) MICE TO DEVELOP SUBSEQUEND MODELS FOR THE DEVELOPMENT OF IMMUNOTHERAPEUTICS UTILIZING IN PART TECHNOLOGY THAT WE HAVE DEVELOPED FOR THE ONPLANT METASTASIZING OTRHOTOPI ...

A NUMBER OF MONOCLONAL ANTIBODIES (MABS) SPECIFIC FOR TUMOR-ASSOCIATED ANTIGENS HAVE BEEN ANALYZED FOR IMMUNOLOCALIZATION AND/OR TUMOR-GROWTH INHIBITION IN ATHYMIC MICE BEARING SUBCUTANEOUSLY TRANSPLANTED HUMAN XENOGRAFTS DERIVED FROM TUMOR CELL LINES. ALTHOUGH THE SUBCUTANEOUS-TRANSPLANT NUDE-MOUSE MODEL IS WELL ACCEPTED FOR THE IN VIVO EVALUATION OF MAB-TARGETING, SOME NEGATIVE ASPECTS NEED TO B ...