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A MAJOR LIMITATION IN CURRENT LARGE SCALE GENOME MAPPING METHODOLOGY IS THAT FEW TOOLS EXIST FOR GENERATING SPECIFIC DNA FRAGMENTS IN THE MEGABASE SIZE RANGE. THIS PHASE I RESEARCH IS EXAMINING THE FEASIBILITY OF DEVELOPING A FAMILYOF INTRON-ENCODED SITE-SPECIFIC ENDONUCLEASES CAPABLE OF GENERATING DNA FRAGMENTS 2 TO 100 MEGABASES IN SIZE BY USINGTHE FOLLOWING STEPS: (1) DEVELOP METHODS FOR EXPRES ...

THE OBJECTIVE OF THIS RESEARCH PROJECT IS TO DEVELOP IMPROVED AMPEROMETRIC BIOSENSORS BASED ON NEW POLYMERIC ELECTRON RELAY SYSTEMS THAT CAN ELECTROCATALYTICALLY REOXIDIZE THE NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD) COFACTOR. THE NAD-DEPENDENT DEHYDROGENASES CONSTITUTE THE LARGEST GROUP OF REDOX ENZYMES KNOWN TODAY. BY USING THIS METHOD OF FACILITATING ELECTRON TRANSFER FROM THE ENZYME TO THE ELEC ...

THE PURPOSES OF THIS PROJECT ARE (1) TO DEVELOP AN OPERATIONAL ELECTRO-OPTICAL OUTPUT DEVICE FOR SUPERCONDUCTING CIRCUITS THAT WILL ALLOW THE IMPLEMENTATION OF HIGH DENSITY OPTICAL INTERCONNECTS AND (2) TO ESTABLISH MINIMUM DESIGN RULES FOR ITS IMPLEMENTATION. THIS PROJECT EXPANDS ON PREVIOUS WORK IN OPTICAL EFFECTS IN SUPERCONDUCTING DEVICES. DEVICE CHARACTERIZATION INCLUDES, BUT IS NOT LIMITED T ...

HYPRES PROPOSES TO DEVELOP A HIGH-SPEED FLASH ANALOG-TO-DIGITAL CONVERTER IN LOW TC SUPERCONDUCTOR TECHNOLOGY (NIOBIUM). CIRCUIT SIMULATIONS HAVE SHOWN THAT THE PROPOSED CIRCUIT IS CAPABLE OF DIGITIZING INPUT BANDWIDTHS UP TO 10 GHZ WITH 4-BITS OF ACCURACY OF HIGHER RESOLUTION AT LOWER BANDWIDTHS (SEE ATTACHED PAPER BY HERBERT KO, 1988 APPLIED SUPERCONDUCTIVITY CONFERENCE PROCEEDINGS, P.826). IN P ...

THIS PROJECT EMPLOYS A TWO-PART DESIGN STUDY FOR HIGH CURRENT, HEAVY ION, RECIRCULATING INDUCTION ACCELERATORS FORINERTIAL FUSION INVOLVING: (1) MODULATOR CIRCUIT DESIGN FOR RECIRCULATING ACCELERATORS, BASED PARTICULARLY ON RECENT ADVANCES IN HIGH POWER SWITCH TECHNOLOGY, AND (2) OPTIMUM RECIRCULATOR DESIGN TO MAKE THE BEST USE OF ADVANCES IN THE SWITCHES AND CIRCUITS. RECENT DOE STUDIES HAVE SHOW ...

MEASUREMENTS AND CALCULATIONS MADE IN THE SOVIET UNION INDICATE THE POSSIBILITY OF USING A NEW CAPILLARY-BASED X-RAY OPTICAL SYSTEM TO INCREASE THE INTENSITY AND DECREASE THE DIVERGENCE OF LABORATORY X-RAY SOURCES SUFFICIENTLY FOR THEM TO COMPETE WITH, AND IN SOME CASES EVEN SURPASS, SYNCHROTRON SOURCES FOR SOME APPLICATIONS. THIS PHASE I PROJECT IS INVESTIGATING THE FEASIBILITY OF SUCH SYSTEMS BA ...

A NEED EXISTS TO MONITOR VIBRATION IN HIGHWAY BRIDGES. IT IS DESIRABLE TO MONITOR MANY POINTS ON THE BRIDGE. THE CURRENT PROBLEM IS THAT SENSORS MUST BE WIRED TO A CENTRAL LOCATION. WIRE IS DIFFICULT TO INSTALL AND TO MOVE. THE SOLUTION IS TO COLLECT SENSOR DATA BY RADIO. A SYSTEM EXISTS THAT ELIMINATES WIRE. IT GATHERS SENSOR DATA TO A CENTRAL LOCATION BY RADIO. THE SYSTEM'S UNIQUE FEATURE IS THA ...

A 3-DIMENSIONAL ATTITUDE SENSOR WHICH USES GPS CARRIER PHASEINTERFEROMETRY IS PROPOSED FOR ANALYSIS AND CONCEPT TESTING IN PHASE I, AND PROTOTYPING IN PHASE II. THE RESULTING SENSOR WILL BE ACCURATE AT ANY LATITUDE. ADROIT SYSTEMS PROPOSES TO ENHANCE ITS SUCCESSFUL 2-DIMENSIONAL, STATIC GPSATTITUDE DETERMINING SYSTEM (ADS) SO THAT IT WILL OPERATE UNDER DYNAMIC CONDITIONS WHILE MEASURING 3-DIMENSIO ...

THIS PROJECT IS DEVELOPING A NEW SOLID-STATE BIOSENSOR TECHNOLOGY FOR BIOLOGICAL MEASUREMENTS. THIS TECHNOLOGY IS BASED ON THE MERGING OF TWO RELATIVELY DIFFERENT TECHNOLOGIES: NUCLEIC ACID PROBES (DNA HYBRIDIZATION TECHNOLOGY) WITH ACOUSTIC PLATE MODE (APM) MICROSENSORS. RECENT ADVANCES IN THE DESIGN AND OPERATION OF APM DEVICES HAVE DEMONSTRATED A DNA HYBRIDIZATION SENSOR PRINCIPLE WITH EXCELLEN ...

THE DEEP CLEANING PROCESSES NOW UNDER INVESTIGATION FOR COAL MOST OFTEN INVOLVE PULVERIZING AND THE USE OF A LIQUID PROCESS MEDIUM. IF THE VERY FINE DEEP CLEANED COAL IS TO BE USED IN A DRY FORM, A SATISFACTORY DRYING TECHNOLOGY IS VITAL. PREVIOUS STUDIES HAVE INDICATED A SUBSTANTIAL PROBABILITY OF SUCCESS IF THE ULTRAHIGH LEVELS OF CENTRIFUGE GRAVITY ARE COMBINED WITH THE CENTRIFUGAL DECANTING/FI ...