Award Data

THE LONG-TERM OBJECTIVE IS TO DEVELOP A COMPUTER-BASED YOUTH SUBSTANCE ABUSE FITNESS LIFE SKILLS TRAINING PRODUCT FOR HEALTH PROFESSIONALS, USING STATE-FO-THE-ART HARDWARE AND SOFTWARE TECHNOLGOY. A SYSTEMATIC CURRICULUM REQUIRING SIXTY-FOUR HOURS OF CLASSROOM TRAINING HAS BEEN DEVELOPED FOR HEALTH PROFESSIONALS TO DELIVER THE FITNESS LIFE SKILLS MODEL. HOWEVER, THE LENGTH AND EXPENSE REQUIRED TO ...

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THE CILIARY GANGLION INNERVATES SEVERAL IMPORTANT EYE TISSUES, INCLUDING THE CILIARY MUSCLE AND BODY, AND HAS BEEN SHOWN TO REGULATE AQUEOUS OUTFLOW AND ACCOMMODATION. THE EYE DISORDERS, GLAUCOMA AND PRESBYOPIA, MAY INVOLVE THE CILIARY GANGLION THROUGH ITS REGULATION OF AQUEOUS OUTFLOW AND VISUAL ACCOMMODATION. A SUBSTANCE THAT COULD DIRECTLY AND SPECIFICALLY STIMULATE THE CILIARY GANGLION MAY BE ...

ANTIVIRAL AGENTS FOR THE TREATMENT FOR HUMAN IMMUNODEFICIENCY VIRUS (HIV-1) ARE DEARLY IN GREAT NEED. WE HAVE SYNTHESIZED AND DONE PRELIMINARY EXPERIMENTS WITH A TRIPLE HELIX FORMING OLIGONUCLEOTIDE DESIGNED TO BIND TO CRITICAL REGULATORY REGIONS IN THE PROVIRAL GENOME OF HIV-1. PRELIMINARY DATA SHOW THAT COMPOUND INHIBITS VIRAL P24 PRODUCTION IN A CHRONICALLY INFECTED MONOCYTE CELL LINE. THE PRIM ...

IMMUNOLOGIC REJECTION IS THE LEADING CAUSE OF FAILURE OF RENAL TRANSPLANTATION. THE OBJECTIVE WILL BE TO DEVELOP AN ASSAY FOR MONITORING KIDNEY TRANSPLANT RECIPIENTS FOR THE ONSET OF GRAFT REJECTION AND TO HELP DISTIGUISH GRAFT REJECTION FROM OTHER RENAL AND EXTRARENAL PROBLEMS IN THESE PATIENTS. SINCE IMMUNOLOGIC ATTACK ON THE RENAL TUBULES IS THE PRIMARY CAUSE OF REJECTION, AN ASSAY THAT MEASURE ...

OF 28 MILLION AMERICANS OVER AGE 65, 8.5 MILLION LIVE ALONE. MORE THAN 50 PERCENT SUFFER FROM SUCH CHRONIC AILMENTS AS ARTHRITIS, HYPERTENSION, AND HEART DISEASE, ALL OFTEN REQUIRING DAILY MEDICATION. U.S. PUBLIC HEALTH RECORDS ESTIMATE THAT 125,000 DEATHS OCCUR EACH YEAR FROM THE MISUSE OF CARDIOVASCULAR DRUGS ALONE, AND THAT ONE IN EVERY TWO PATIENTS TAKING MEDICINE REGULARLY MAKES ERRORS SUFFIC ...

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WE WILL CONSTRUCT CHICKEN KH MOUSE HYBRIDOMA CELL LINES SECRETING CHICKEN MABS TO SELECTED ANTIGENS. A PRIMARY ADVANTAGE IN THE CONSTRUCTION OF THESE HYBRIDOMAS IS THE GENETIC DIFFERENCES BETWEEN CHICKENS AND MAMMALS WHICH INCREASES THE CHANCE OF PRODUCING ANTIBODIES AGAINST HIGHLY CONSERVED REGIONS OF MAMMALIAN PROTEINS SUCH AS PEPTIDE HORMONES AND GROWTH FACTORS. BECAUSE OF THIS GENETIC DIFFEREN ...