Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Development of a rapid diagnostic assay for Myasthenia Gravis

    SBC: Attogene Corporation            Topic: 101

    Project Summary AbstractThe physiological effect of autoantibody binding to the motor endplate junction nicotinic acetylcholine receptorsAchRcauses numerous symptoms associated with Myasthenia GravisMGand is characterized by drooping of one or both eyesblurred or double visionchange in facial expressiondifficulty swallowingshortness of breathimpaired speech and weakness of muscle functionIn some c ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Development and Optimization of MNK Inhibitors for the Treatment of Neuropathic Pain

    SBC: 4E THERAPEUTICS INC.            Topic: 104

    Abstract The goal of this project is to develop an optimized MNK inhibitor for neuropathic pain treatmentMNK is a kinase that phosphorylates eIF E to control the translation of a distinct subset of mRNAsOur focus on this target for neuropathic pain is grounded in evidence that MNK eIF E signaling is activated in nociceptors upon exposure to pain promoting cytokines and growth factors as well as by ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Advance Early Detection of Lupus Nephritis with ClearGold

    SBC: CLEARNANO INC            Topic: 400

    SummarySystemic lupus erythematosusSLEor lupus is an autoimmune disease that impacts more thanmillion people worldwideincludingmillion AmericansNearlyof these patients will develop lupus nephritiswhich can cause kidney failureAs a resultits financial burden to individual patient can reach $yearmuch higher than many other diseases because of kidney transplantationAlthough early treatment of lupus n ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Novel Strategies for Development of a Multiplexed Test with Expanded Content for Spinal Muscular Atrophy

    SBC: ASURAGEN, INC.            Topic: 102

    SummaryThe overall goal of this project is to develop a cost effective multiplexed diagnostic test for spinal muscular atrophySMAto rapidly and accurately analyze multiple classes of disease causingdisease modifying DNA variantsand carrier status markersUltimatelythe proposed test will have a far reaching impact by expanding the identification and stratification of patients who may benefit from ne ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. STTR Phase I Development of Novel Antibacterial and Antifungal Bioadhesive Biomaterials for Diabetic Skin Wound Healing

    SBC: Dynamic Entropy Technology, LLC            Topic: NIDDK

    Abstract Diabetic ulcers or pressure ulcers are common for patients with diabetesspinal cord injuriesetcWithout proper managementsuch wounds often lead to infections such as osteomyelitis or sepsisresulting in high mortality and morbidityIn addition to bacterial infectiondiabetic patients are also more susceptible to cutaneous fungal infectionsAdvanced wound dressings and advanced wound therapies ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Preclinical studies to validate the efficacy of novel mechanism-of-action small molecule inhibitors to treat Duchenne muscular dystrophy

    SBC: RIDGELINE THERAPEUTICS LLC            Topic: NIAMS

    Progressive muscle weakness and degeneration is a hallmark of Duchenne muscular dystrophyDMDIn DMD patientsthe lack of dystrophin reduces muscle fiber structural integritymaking muscles vulnerable to persistent injury and damageRepairing these damaged muscles requires the continual activation of muscle stem cellsmuSCwhich leads to muSC dysfunction and senescenceand ultimately the muscle degenerati ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Transcutaneous auricular neurostimulation for neonatal abstinence syndrome

    SBC: SPARK BIOMEDICAL INC            Topic: R43

    Neonatal abstinence syndromeNASis a condition in which infants undergo withdrawal after exposure to prescription or non prescription opioids such as methadone or heroin in uteroNAS babies exhibit hyperirritability of the central nervous system and respiratorygastrointestinaland autonomic symptomsThese symptoms usually appear withintohours after birthAs ofan infant with NAS was born everyminutes in ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Next Generation Tools for Onsite Monitoring and Treatment of Drug of Abuse-Dependent Persons

    SBC: SensoDX II, LLC            Topic: NIDA

    Abstract Opioid abuse disorderOADaffectsmillion of Americans annually resulting in overdoses numbering in the tens of thousands and skyrocketing rates of mortalityIn addition to its enormous social impactOAD carries a multi billion dollar price tag that includes $billionspecifically for health care and other costs related to prescription opioid abuse and misuseAlthough effective interventions exis ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Incubator-based active noise control system validation in realistic NICU environment

    SBC: Invictus Medical, Inc.            Topic: NIDCD

    The aural stimulation of the hospitalized infant in the neonatal intensive care unitNICUfrom alarmsventilatorsphonesconversationsand air handling system is linked to a myriad of problemsboth acute and long termThe stress resulting from the noise has a negative effect on vital signsweight gainand quality of sleep in the short term and in the long term with hearing loss and language deficitEfforts t ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Accelerating Functional Maturation of Human Neurons for High-Throughput Screening

    SBC: BrainXell, Inc            Topic: 44

    Project Summary AbstractNeurological and psychiatric disordersincluding drug abuse and addictionexert a devastating personal and economic toll on patientsfamiliescaregiversand societyThis is in part due to our failure in developing effective medicationswhich in turn is due to the use of drug discovery platforms that are often not relevant to target diseasesThe recent development of induced pluripo ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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