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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. SBIR TOPIC 97- PHASE II- MINIMALLY INVASIVE TEST FOR CHEMOTHERAPY-INDUCED CARDIOTOXICITY

    SBC: ACCEL DIAGNOSTICS, LLC            Topic: NHLBI

    Cardiovascular toxicityCVTxis a serious short and long term complication of many anti cancer chemotherapeutic regimensZamoranoLancellotti et alIn this PhaseSBIR submission to continue the development and validation of Accel Diagnosticsminimally invasiverapidcost effective and connected blood testthe pScreen CVTx TMfor the early detection and continuous of chemotheropy induced CVTx

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Rapid, Accurate Point-of-Care Test for Gonorrhea and Determination of Antimicrobial Susceptibility

    SBC: AI BIOSCIENCES, INC.            Topic: NIAID

    Antimicrobial resistant gonorrheacaused by Neisseria gonorrhoeaeNGhas become an urgent threat for global public healthThe goal of this project is to develop a one hour point of care diagnosticPOCtest capable of identifying NGand determining the infecting strain s susceptibility to antibioticsAI Biosciences plans to achieve this goal by expanding the capability of its POC system being developed for ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Advanced development of a novel nanoparticle conjugate vaccine for Salmonella Paratyphi A

    SBC: KJ Biosciences LLC            Topic: NIAID

    Salmonella Paratyphi ASParatyphi Ais a major cause of life threatening enteric feverThere is no vaccine available against this pathogenIn the SBIR phase I studieswe have successfully demonstrated the technical feasibility of a novel nanoparticle conjugate vaccine candidate for SParatyphi AIt is based on O polysaccharideOPSantigen conjugated to a novel and highly advantageous nanoparticle protein c ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Development of Aptamer Affinity Reagents to Immune Targets in Non-human Disease Models

    SBC: Base Pair Biotechnologies, Inc.            Topic: NIAID

    This goal of this program is to address the limited availability of reagentsantibodiesproteinsligandsfor the identification and discrimination of immune cells and the characterization of immune responses in nonmammalian models and mammalian models for which immunologic reagents are limitede gguinea pigferretcotton ratFor examplethe progression of disease that follows infection of guinea pigs with ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. NCATS SBIR 2019 PHASE I PROPOSALS TOPIC 018 ENTITLED NON-PDMS BIOCOMPATIBLE ALTERNATIVES FOR ORGANS-ON-CHIPS

    SBC: Lynntech Inc.            Topic: NIDA

    Microfluidic organ on a chipOOCsystems offer a distinct advantage over existing in vitro systems through incorporation of micro architecture to a cultured cell line sthat structurely and mechanically mimic more closely in vivo physiological conditions in an in vitro constructThese OOC devices are typically constructed from polydimethylsiloxanePDMShoweverPDMS has several drawbacks that can impact t ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Decentralized, Public, and Mobile-Based Sidewalk Inventory Tool

    SBC: KNOWLEDGE BASED SYSTEMS, INC.            Topic: 142FH1

    Knowledge Based Systems, Inc. (KBSI) is pleased to propose the further design and development of MySidewalk mobile application facilitating the crowd-sourced collection of sidewalk inventory and condition data. The MySidewalk application utilizes advances in social networks and data mining to provide integrated sidewalk datasets. Phase I and II research was facilitated by inputs from City of Colle ...

    SBIR Phase II 2019 Department of Transportation
  7. A Large-Scale Microfluidics Imaging Platform for High-Throughput Toxicity Testing using Canine Intestinal Organoids

    SBC: Newormics, LLC            Topic: NIEHS

    Project SummaryCurrentlytoxicology studies require a large number of animal testing to identify better and safer drug candidatesIn an attempt to reduce the use of large animals in pharmaceutical industrythere is a need to bridge the gap between the conventional in vitro cell based assay and the non human animal studiesRecentlythreedimensional models are gaining momentum and replacing conventionalD ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Preformulation and formulation development of Fenrock, an Abuse-resistant Fentanyl Transdermal Patch

    SBC: PAIN THERAPEUTICS, INC.            Topic: NIDA

    Project Summary Abstract Under this Fast Track proposalwe will develop Fenrockan abuse deterrent transdermal fentanyl patch based on our proprietary co crystal of naltrexoneNTXand its carefully selected conformermethyl furfuralMFFThis NTXMFFco crystalNTX Cohas the desired properties to stay in a crystalline solid form in the patch when applied to skin as intended but to dissociate to deliver NTX w ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Development of a Neonatal Abstinence Syndrome Therapy

    SBC: Mu Therapeutics Inc.            Topic: NIDA

    Project Summary Neonatal Abstinence SyndromeNAShas skyrocketed in recent years as a result of the opioid epidemic plaguing this countrySincethe number of babies affected by NAS has increased nearlyfoldEveryminutes a baby is born suffering from opioid withdrawaloften prematurely with developmental problems and potential long term adverse effects including cognitive impairmentApproximatelyof pregnan ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Passive Exoskeleton for Children with Neuromuscular Disorders

    SBC: RUSH RIVER RESEARCH CORPORATION            Topic: NICHD

    Project Summary Abstract Rush River ResearchRRRCorporation proposes to develop and commercialize a novel passive exoskeleton that helps young children with very little residual strength to use their armsThe proposed orthosis could help the overchildren with many different neuromuscular disorders including muscular dystrophyspinal muscular atrophycerebral palsyarthrogryposis multiplex congenitalAMC ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health

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