Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Endotoxin Neutralization as a Biomonitor for HIV Disease Progression

    SBC: BIODTECH, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Endotoxin neutralization in human plasma is an excellent indicator of chronic immune activation, which is the most accurate predictor of mortality in HIV. Recently we developed an assay using endotoxin neutralization asan indicator of bacterial translocation. This assay is accurate in discriminating control patients from those with inflammatory bowel disease in ...

    SBIR Phase I 2014 Department of Health and Human Services
  2. Preclinical Studies of PG70 LEAPS Peptide Vaccines for Rheumatoid Arthritis

    SBC: CEL-SCI CORPORATION            Topic: NIAMS

    DESCRIPTION (provided by applicant): Currently, FDA-licensed pharmaceuticals used to treat rheumatoid arthritis (RA) focus largely on alleviation of symptoms, either through pain management, general immunosuppression, or by antagonizing cytokines such as TNF-?. Despite recent advances in biologic therapies, these treatments do not address the underlying autoimmune condition. Ligand epitope antigen ...

    SBIR Phase I 2014 Department of Health and Human Services
  3. Topically-delivered Mutation-specific Gene Targeting for Epidermolytic Ichthyosis

    SBC: Exicure, Inc.            Topic: NIAMS

    DESCRIPTION (provided by applicant): AuraSense Therapeutics (AST), along with Northwestern University, is applying a recently developed technology using oligonucleotide-functionalized nanoparticles (called spherical nucleic acids or SNAs) to control protein expression. These easily synthesized nanoparticles can have either DNA or RNA shells, and are less than 50 nm in hydrodynamic diameter. SNA co ...

    SBIR Phase I 2014 Department of Health and Human Services
  4. Assessment of Hypercoagulability in Cancer Patients Using Sonorheometry

    SBC: HEMOSONICS            Topic: NCI

    DESCRIPTION (provided by applicant): The Problem: Venous thromboembolism (VTE), which encompasses the diseases of deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common and life-threatening problem amongst cancer patients. In population-basedstudies, cancer has been associated with a 4-fold increase risk for VTE; in cancer patients undergoing systemic chemotherapy treatment the risk i ...

    SBIR Phase I 2014 Department of Health and Human Services
  5. New High Throughput Anti-Tumor Drug Screening System

    SBC: Vivo Biosciences Inc            Topic: NCI

    DESCRIPTION (provided by applicant): This SBIR project is focused to develop, validate and commercialize an advanced high-throughput anti- tumor drug screening platform (HTS) which employs a new 3D HuBioGEM assay technology. Preclinical drug screening is commonly performed using biochemical and cell-based assay systems. In recent years, more relevant 3D spheroid models have been developed using mi ...

    SBIR Phase I 2014 Department of Health and Human Services
  6. Development of a new anti-inflammatory peptide for treatment of type II diabetes

    SBC: SERPIN PHARMA, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Type II diabetes (T2DM) affects more than 5% of the population in Western countries. In the US alone, about 23.6M children and adults have diabetes, and the associated cost was estimated to 174 billion in 2007. The rise in T2DM prevalence is linked to the dramatically increased incidence of obesity, which now affects about a third of the adult US population. H ...

    SBIR Phase I 2014 Department of Health and Human Services
  7. Chronically Acting CFTR Inhibitor Discovery for Secretory Diarrhea and ADPKD

    SBC: DISCOVERYBIOMED, INC.            Topic: NIDDK

    Project Summary Abstract DiscoveryBioMed, Inc. (DBM) has launched an innovative and automation-friendly drug discovery program to screen a collection of small molecular compounds on a human epithelial cell platform expressing physiologically relevant levels of the wild-type Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) to discover a new class of therapeutic drugs for secretory disease ...

    SBIR Phase I 2014 Department of Health and Human Services
  8. Development of a Centralized Intelligence and Control AP Hub Device

    SBC: TYPEZERO TECHNOLOGIES, LLC            Topic: NIDDK

    ? DESCRIPTION (provided by applicant): Despite major advances in pharmaceuticals and medical device technology, the ability to safely and effectively control blood glucose in patients with Type 1 diabetes has remained a recalcitrant challenge and a significant source of human suffering and economic cost. With the advent of continuous glucose monitoring (CGM), increasing effort has been focuse ...

    SBIR Phase I 2014 Department of Health and Human Services
  9. Human Induced Pluripotent Stem Cell-Derived Beta-Cells for Drug and Toxicity Testing

    SBC: Regenerative Medical Solutions Inc            Topic: NIDDK

    ? DESCRIPTION (provided by applicant): Diabetes represents one of the most serious health crises worldwide. It is estimated by the American Diabetes Association that one person is diagnosed with diabetes every 17 seconds, while the International Diabetes Federation states that one person dies every seven seconds from diabetes. Diabetes growth continues to skyrocket, with over 382 million cases ...

    SBIR Phase I 2014 Department of Health and Human Services
  10. Lead Detection in Soil and Sediment

    SBC: MORPHIX TECHNOLOGIES, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): EPA's Cleaning-Up the Nations Waste Sites: Market and Technology Trends (2004) estimates that there are 294,000 contaminated waste sites in the United States. Characterizing suspected contaminated sites remains difficult, time consuming, and expensive. Samples are typically sent to laboratories for costly testing that can take weeks. While some field det ...

    SBIR Phase I 2014 Department of Health and Human Services
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