Award Data

Project Summary Neurological disorders significantly outnumber diseases in other therapeutic areas and are growing in incidence faster than any other disease classes However the pharmaceutical industry has been unsuccessful in coming up with effective drugs A big factor in these failures has been a lack of adequate model systems for fundamental disease understanding affecting both diagnosis and ...

Summary VisionQuest Biomedical LLC VisionQuest has developed a diabetic retinopathy DR screening system EyeStar enabled by automated screening software DR RACS that was developed under the EY Phase II SBIR project Our product provides immediate feedback to the physician on the state of diabetic eye disease without burdening an eye care specialist to review those cases without retin ...

ABSTRACT Extracorporeal membrane oxygenation ECMO use continues to increase as a supportive measure for cardio respiratory failure Pediatric patients with severe acute left ventricular LV systolic dysfunction are often supported with venoarterial VA ECMO as a short term bridge to recovery transplant or a ventricular assist device VAD Although this often provides the much needed tempora ...

Abstract Prospective cohort studies in individuals at risk for Type diabetes T D have established that diagnosis of the disease occurs at a late stage in the progressive decline in cell function when the majority of cell function has been lost and the possibility for disease prevention is gone Current measures of autoantibodies HLA typing and oral glucose tolerance tests OGTT are abl ...

Abstract Alzheimerandapos s disease AD is one of the leading causes of death among aged people and currently more than million people have AD in the US alone Although there is no cure for AD studies indicate that clinically proven medicines have the ability to slow ADandapos s progress especially if they are administered early on Obviously to develop diagnostics that are able to detect ...

DESCRIPTION provided by applicant Systemic sclerosis scleroderma SSc is a chronic autoimmune disease characterized by proliferative vascular lesions with resultant fibrosis of skin and other multiple organs including the gastrointestinal GI tract In the United States the prevalence of SSc is about per million in adults Up to of SSc patients are reported to have upper and lower ...

DESCRIPTIONprovided by applicantFunctional magnetic resonance imagingfMRIhas become one of the leading research tools to study brain function and is playing a pivotal role in several large scale brain mapping projects worldwideDespite ongoing technical advancements in MRI which have greatly increased its availability and helped improve the resolution for functional brain mappingwe still have very ...

Clostridium difficile infectionthe cause of antibiotic associated pseudomembraneous colitisis a growing national health problemThe incidence of primary Clostridium difficile infection in the hospitalized U Spopulation is greater thancases annuallyThere is a high incidence of relapseCdifficile infection is also a significant problem among patients with ulcerative colitisThis infection is often diff ...

ABSTRACT The goal of this application is to evaluate the cancer therapeutic feasibility of CanCureandapos s humanized first in class immunostimulatory monoclonal antibody mAb huB G the Product also names CuraB During cancer development in response to oncogenic insult or stress almost ALL human cancer cells are induced to express a SURFACE molecule MIC MHC I chain related Molecule wh ...

DESCRIPTION provided by applicant This is a SBIR Phase I application to develop new iron chelating drugs for prevention and treatment of iron overload induced bone loss in patients with thalassemia major TM a rare disease in the US Virtually all TM patients are affected by osteopenia and osteoporosis and these skeletal complications herald and contribute to a general clinical deterioratio ...