Award Data

DESCRIPTION (provided by applicant): C. perfringens epsilon-toxin (ETX) is a potential biological weapon included in the list of category B priority agents. The overall goal of this proposal is to identify and perform in vivo testing of new inhibitors of E TX using a novel approach for the inactivation of pore-forming toxins developed at Innovative Biologics, Inc. It is based on the blocking of th ...

DESCRIPTION (provided by applicant): Lung transplantation is the only effective treatment modality for patients with end-stage lung disease. Ischemia-reperfusion injury, associated with the retrieval, storage and transplantation of the lung is a major immu ne-independent factor adversely affecting early graft function, graft viability and recipient morbidity and mortality. Marginal donor lungs, ar ...

DESCRIPTION (provided by applicant): Sphingolipids are being increasingly recognized as key mediators of inflammatory cascades of critical importance in multiple diseases, including rheumatoid arthritis and osteoarthritis. Most importantly, sphingosine 1-phosphate produced by sphingosine kinase (SK) mediates the effects of tumor necrosis factor-1 and interleukin-12, pro-inflammatory cytokines ...

DESCRIPTION (provided by applicant): The long-term objective of the research is to develop and fabricate an instrument that can facilitate the discovery of new drugs via high throughput screening (HTS). ECIS (electric cell-substrate impedance sensing) is a technology developed by Applied BioPhysics to study the behavior of cultured cells in real time. Instruments manufactured by the company curre ...

DESCRIPTION (provided by applicant): Long-term Objectives Aims: Sexual dysfunction is the most common long-term consequence of cancer treatment, affecting half of survivors of breast and gynecological cancer and many women treated for other cancers. Yet, f ew women get the help they need for sexual problems. Our primary objective is to develop and evaluate a multimedia intervention program for wom ...

DESCRIPTION (provided by applicant): The proposed research involves the development of assistive technology that is based upon a force-feedback joystick. The Barron Associates Joystick Appliance (BAJA) is targeted at individuals with neuromuscular problems in their arms and/or hands and will compensate for many deficiencies in the operator's own movement capabilities, including lack of strength, ...

DESCRIPTION (provided by applicant): Bio-Signal Group Corp. developed a miniature, battery-operated, multi-channel, portable digital telemetry system to record wideband bioelectric signals. DT measures biopotentials with high precision because it digitiz es signals on the subject at 24-bit resolution. Perhaps the most obvious feature that distinguishes the DT from other telemetric systems is the ...

DESCRIPTION (provided by applicant): Cell Preservation Services, Inc. (CPSI) is a biotechnology company dedicated to the development of novel technologies in the area of low temperature biology and medicine. CPSI's core molecular strategy is focused on und erstanding and manipulating the cell survival and cell death pathways that appear to be cell-specific and are activated as a consequence of low ...

DESCRIPTION (provided by applicant): Linomide is a known anti-inflammatory drug. Recently we have synthesized a new analog of Linomide, linomide-5. The objective of this proposal is to develop linomide-5 as a therapeutic for treating diabetic retinopathy ( DR) and age-related macular degeneration (AMD). Together, these diseases constitute the major causes of blindness worldwide. In both cases, ret ...

DESCRIPTION (provided by applicant): The long-term goal of this project is to create a sprayable surgical adhesive which would satisfy the surgical need for a strong, easy-to-use adhesive to adhere planar flaps of tissue. This novel adhesive will reduce fl uid accumulation after surgery by eliminating dead space in the wound and maintaining tissues in position for natural healing to occur. Seroma ...