Award Data

N/A

DESCRIPTION (provided by applicant): The primary goal of the current research will be to select the best recombinant form of one of two naturally occurring human igM antibodies demonstrated to stimulate remyelination to further develop for clinical testing in inflammatory demyelinating disease, such as MS. These antibodies, designated sHIgM22 and sHIgM46, were isolated by the Rodriquez laboratory ...

DESCRIPTION (provided by applicant): The development of new treatments for the effective reduction of renal injury associated with acute renal failure and kidney transplantation will have a great impact on health care delivery to patients with renal disease. Acute ischemic renal failure affects 5 percent of hospitalized patients and has a mortality rate approaching 50 percent. At present, dialysis ...

epsis syndrome is the 11th leading cause of death in the United States ( about 900,000 new cases per year) with a mortality of about 35 percent. The need for adjunctive therapies is urgent. In Phase I of this SBIR award we documented the anti-inflammatory effects of adenosine A2A receptor (A2AAR) agonists on isolated immune cells and have observed ramatically improved survival in mouse models of I ...

DESCRIPTION (provided by applicant): The central goal of this research is to develop a new drug to prevent spinal cord reperfusion injury secondary to aortic clamping that occurs frequently during thoracic surgery. Irreversible spinal cord injury resulting in paraplegia or paraparesis is the single most devastating complication of surgery on the thoracic and thor ...

DESCRIPTION (provided by applicant): The AccuNurse System has been successfully developed in Phase I to provide an easy-to-use "mentor" and communications tool for CNAs and nurses in skilled nursing units. Wireless and advanced speech technologies are merged into a conversational system that provides: individualized resident information, paperless documentation at the point of care, and many other ...

This application addresses the need for an alternative to pharmacological treatment of children diagnosed with ADHD (and other conditions that may present motoric excess). Technological enhancements to the Phase I Feedback Actigraph, now referred to as BuzzBee¿, will allow multiple activity recorders (belt-worn by ADHD diagnosed children) equipped with vibrotactile, auditory, and visual feedback ...

The trend toward replacement of highly toxic chemicals with less hazardous alternatives has created the demand for replacement of chromate conversion coatings for corrosion protection of aluminum alloys. Aluminum alloys are the predominate structural material used in aircraft because of their high strength-to-weight ratios, affordability and processability. Aluminum is subject to catastrophic fail ...

Cardiovascular disease is the leading cause of morbidity and mortality in the US, afflicting over 58 million Americans. Angiogenic factors can increase vascularization and improve perfusion in ischemia. Scatter factor/hepatocyte growth factor (SF/HGF) may be superior to other angiogenic factors because of multiple actions on components of the angiogenic cascade and anti-apoptotic properties. Our P ...

DESCRIPTION (provided by applicant): Efforts will be made to produce Thin Film Phantom systems that enables the precise placement of sub-resolvable 'digital scatterers' on a acoustically transparent supporting media in a tissue mimicking fluid. Research will include not only the continued study on tissue mimicking material, supporting medium, and materials for digital scatterers but expanding app ...