Award Data

DESCRIPTION (provided by applicant): The central goal of this research is to develop a new drug to prevent spinal cord reperfusion injury secondary to aortic clamping that occurs frequently during thoracic surgery. Irreversible spinal cord injury resulting in paraplegia or paraparesis is the single most devastating complication of surgery on the thoracic and thor ...

epsis syndrome is the 11th leading cause of death in the United States ( about 900,000 new cases per year) with a mortality of about 35 percent. The need for adjunctive therapies is urgent. In Phase I of this SBIR award we documented the anti-inflammatory effects of adenosine A2A receptor (A2AAR) agonists on isolated immune cells and have observed ramatically improved survival in mouse models of I ...

DESCRIPTION (provided by applicant): The AccuNurse System has been successfully developed in Phase I to provide an easy-to-use "mentor" and communications tool for CNAs and nurses in skilled nursing units. Wireless and advanced speech technologies are merged into a conversational system that provides: individualized resident information, paperless documentation at the point of care, and many other ...

DESCRIPTION (provided by applicant): This Phase II SBIR grant will enable the continued development of a unique and comprehensive research resource, the Protein Catabolism Database (PCDB), which will enable scientists to build upon a wealth of information to accelerate basic research and drug target identification. PCDB focuses on the field of protein catabolism, aberrations of which are implicate ...

DESCRIPTION (provided by applicant): The overall goal of the ADEPT project is to enhance the independence, autonomy, safety, and performance of patients with dementia in conducting activities of daily living (ADL). The overall objective of ADEPT development is to enhance patient care in Special Care Units (SCUs) through the further development and testing of a computerized, self-directed, traini ...

DESCRIPTION (provided by applicant): Limb-shortening deformities and bone segmental defects remain among the most difficult challenges faced by patients and orthopaedists. Traditional techniques to correct these problems rely primarily on transverse pins or wires, which are subject to pain, scars, contractions, and risk of infection. The Phase I research demonstrated the feasibility of a new metho ...

DESCRIPTION (provided by applicant): In Phase I Kestrel Corporation developed and demonstrated a retinal imaging system that combines multispectral imaging techniques with adaptive optics and image deconvolution to provide high resolution less than (

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The proliferation of nuclear, biological, and chemical weapons continues to pose a threat to U.S. national security. The threat to armed forces can be reduced by early detection of deleterious agents prior to any human contact. The probability of usingsuch weapons by a hostile force increases as they become more prevalent. This further emphasizes the need for field deployable systems that are c ...