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? DESCRIPTION (provided by applicant): The incidence and prevalence of both alcoholic and non-alcoholic liver diseases is increasing. The population presenting with Metabolic Syndrome, a key risk factor for NAFLD-NASH-liver fibrosis is ballooning. Leftuntreated, liver fibrosis can progress to cirrhosis or end-stage liver disease and even hepatocellular carcinoma. Today, therapeutic strategies ...

DESCRIPTION: Incremental improvements in label free screening technologies over the past decade have not produced the capability necessary to support the changing needs of drug discovery programs. Persistent artifacts related to non-specific binding, promiscuous binding, precipitation, complex binding, tubing retention, aggregation, and sub-optimally designed platforms continue to hinder progress ...

This proposal was submitted under the Small Business Innovative Research (SBIR) Fast-track process. In Phase I, that concluded in September, 2014, the primary purpose was to develop a sensor-enhanced health information system for many different health contexts including prevention and management of chronic diseases such as cancers. In Phase II, Vignet will combine several innovative technologies a ...

To hijack the execution of a program, an attacker must overwrite the value of a return address or a function pointer (broadly defined). To prevent program hijacking, our product will provide a layered defense of these two targets, including deterministic and randomization defenses, with the ability in many cases to continue execution after a hijacking attempt is prevented. Our product toolkit incl ...

In order to better protect critical infrastructure from cyber attacks, perimeter and passive defenses must be complemented with an active defense mechanism which elevates the risks, or costs, a potential attacker will face. The effectiveness of an active defense mechanism, however, is ultimately limited by its ability to detect threats fast, accurately, and reliably. For this Phase II project, we ...

Our objective is to develop an innovative cognitive knowledge-aided information processing framework to take very high rate intelligence data streams over wide areas and autonomously highlight Areas-of-Interest (AOIs) and targets for the image analyst without a priori knowledge of the area or location of the individual high interest targets. By using 100s of JADE based intelligent agents in Phase ...

Existing information extraction technology can only partially address the problem of exploiting unreadably-large amounts text. When discussion of events is limited to simple, past-tense, factual descriptions of events, current NLP-based systems can ident

Deployment of unmanned systems continues to expand across a wide range of missions; for example, logistics and resupply missions, force application and protection, and improving battlespace awareness. Presently these unmanned systems run at the lowest of four possible levels of autonomy, that is, in a teleoperated mode, and each system typically requires multiple operators. To address this proble ...