Award Data

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DESCRIPTION (provided by applicant): Research is proposed to improve and extend an existing, successful, commercial electronic forms product line whereby documents can be filled out either online or offline, electronically signed and then securely transmitted over the Internet. A system based upon this technology would allow research institutions to utilize FREE, Internet downloadable software to ...

DESCRIPTION (provided by applicant): For the 10 million people in the U.S. with Type 2 diabetes, it is essential to follow strict regimens that include diet, weight, exercise, eye care and foot care. The prescribed regimen promotes glycemic control, which is correlated with better health. Many have proposed interventions that are either time/labor intensive and costly (regular phone calls from nu ...

Key advances in obesity research over the last decade have established the prominence of the central nervous system (CNS) in body weight regulation. The goal of the proposed research is to develop a target discovery approach that will mine neurons in the CNS known to express important obesity genes. This goal will be accomplished using recently-developed state-of-the-art techniques to genetically ...

DESCRIPTION (provided by applicant): A need exists for accurate, self-calibrating instrumentation capable of monitoring in real time the concentration of blood alcohol as evidenced by the alcohol content of exhaled breath. At present instrumentation capable of diagnosing breath alcohol content requires selection of a specific sample time, is not readily amenable to continuous monitoring and doe ...

HCV is a widely prevalent RNA virus with 200 million individuals worldwide, and 4 million Americans are chronically infected with HCV. Patients with chronic HCV infection are at risk of developing cirrhosis, liver failure and hepatocellular carcinoma. Rapid diagnosis of HCV can lead to early treatment and prevention of transmission. While enzyme immunoassays for ...

DESCRIPTION (provided by applicant): Realizing important advances in the screening, diagnosis and treatment of cancer depends in large part on the sensitivity, simplicity and cost of detecting specific nucleic acid sequences. Nomadics proposes to adapt amplifying fluorescent polymer (AFP) technology to nucleic acid detection. AFPs are an innovative and important new class of polymers that amplify ...

DESCRIPTION (provided by applicant): Of the numerous biological agents that may be used as weapons, the Working Group on Civilian Biodefense has identified Bacillus anthracis as one of the most serious agents. The most effective defense against this agent on a broad scale is through an aggressive vaccination program. Currently, there is one vaccine for use in the United States for anthrax, produ ...

DESCRIPTION (provided by applicant): We have developed a plant-based adjuvant/carrier:antigen fusion technology that offers significant advantages over conventional injectable vaccination regimes including: safety, mucosal efficacy, ease of delivery, rapid scalability, unlimited supply potential, and cost-savings. This technology has significant potential in contributing to biodefense strategies ...

DESCRIPTION (provided by applicant): This project develops A2A adenosine receptor (A2AAR) agonists as adjuncts to antibiotics for the treatment of anthrax septicemia. It responds to the urgent need for better treatment of highly lethal infections by this bioterrorism/biowarfare agent. Phase I has two aims, pharmaceutical development and documentation of efficacy in clinically relevant settings. Th ...