Award Data

DESCRIPTION (provided by applicant): In this proposal we respond to the call by the National Institute of Environmental Health Sciences (NIEHS) in the PHS 2007-2 Omnibus Solicitation for new products/devices, tools, assays to improve our ability to precis ely measure environmental exposures to individuals with high temporal and spatial resolution. According to the solicitation, the device should ...

DESCRIPTION (provided by applicant): Owing to certain intrinsic advantages of conventional or cable-operated assistive appliances, many upper- extremity amputees prefer using simple voluntary opening (VO) split hook terminal devices for some tasks. Ampute es who regularly contribute their time and expertise helping ADA develop innovative new assistive appliances continue to request the company cr ...

DESCRIPTION (provided by applicant): Cancer treatment today is in need of tumor-specific and effective therapies that do not harm the patient and thereby compromise treatment efficacy and prolong recovery time. A multi-modal therapeutic and imaging agent t hat does not damage healthy living tissue would have tremendous benefit to researchers and victims of this deadly disease. Nanomaterials have t ...

Cancer biomarker detection and cancer proteomics and genomics research require analysis platforms that provide high sensitivity and high throughput. In phase I, we will develop a novel nano-enabled sensing platform that is based on metal nanopillar patterned surface on a continuous Au thin film. This platform provides dramatic sensitivity increase through the combination of fluorescent enhancement ...

DESCRIPTION (provided by applicant): This Small Business Technology Transfer Phase I project will develop a prototype online perchlorate monitor for a resin bed perchlorate remediation reactor. The device will be have less than 4 ppb limit- of-detection, p rovide results in less than 3 min., and require only periodic microchip replacement as routine maintenance. Currently, perchlorate can only be ...

DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project aims to develop a novel dry powder inhalation system, Aktiv-NebTM, for delivering antiviral drug (siRNAs) powders, to the respiratory systems of infants and young children as an intervention strategy for respiratory infection RSV. RSV-specific siRNAs developed by Alnylam Pharmaceuticals, have been demonst ...

DESCRIPTION (provided by applicant): The aim of the work proposed here is to demonstrate the feasibility Encouraging Handwashing Messages (EHM). The intent of EHM is to increase hand hygiene on a hospital floor by rewarding good hand hygiene with a voice m essage praising the listener. In Phase I, EHM will play voice messages at the Weinberg Intensive Care Unit at Johns Hopkins Hospital in Baltimo ...

DESCRIPTION (provided by applicant): Mesenchymal stem cells (MSCs) are one of the most extensively studied adult stem cells and have broad potential uses. A few of their uses include, studying developmental pathways, disease modeling, in vitro toxi cology models, compound screening, humanized animal models and potentially cellular therapy. Although MSC are proliferative, a drawback with th ...

DESCRIPTION (provided by applicant): The proposed study utilizes novel electronics and microfabrication techniques to create scalable, in-vitro Multielectrode Array (MEA) technologies. This research will enable rapid advancements in the study of neural int eractions and in the understanding and treatment of neural disorders. Phase I involves two significant developments for neural related research ...

DESCRIPTION (provided by applicant): The proposed research program focuses on the development of a wireless Small Animal Physiological Monitor (SAM). The SAM system will provide the capability to monitor up to 32 laboratory animals (initially rats and mice ) simultaneously, with continuous recording, synchronization, and display of physiological data, including heart rate, respiratory rate, three ...